Kimber T E, Thompson P D, Kiley M A
Department of Neurology, Royal Adelaide Hospital, North Terrace, Adelaide, SA, 5000, Australia.
J Clin Neurosci. 2008 Feb;15(2):205-8. doi: 10.1016/j.jocn.2006.04.019.
Repetitive and compulsive behaviours can occur in association with the use of dopaminergic medications for the treatment of Parkinson's disease (PD). This syndrome has been referred to as the 'dopamine dysregulation syndrome'. The prognosis for patients with this syndrome is unclear. We report five PD patients in whom the abnormal behaviours resolved completely after withdrawal of dopamine agonist therapy. We alert clinicians to the apparent role of dopamine agonists in this syndrome. In addition, we highlight the potential reversibility of the syndrome, its varied phenomenology and its potential pathophysiology.
重复和强迫行为可能与使用多巴胺能药物治疗帕金森病（PD）有关。这种综合征被称为“多巴胺调节障碍综合征”。该综合征患者的预后尚不清楚。我们报告了5例帕金森病患者，他们在停用多巴胺激动剂治疗后，异常行为完全消失。我们提醒临床医生注意多巴胺激动剂在该综合征中所起的明显作用。此外，我们强调了该综合征的潜在可逆性、其多样的临床表现及其潜在的病理生理学。
