Olivares Martínez Elizabeth, Hernández Ramírez Diego F, Núñez-Álvarez Carlos A, Cabiedes Javier
Laboratorio de Inmunología, Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México D.F., México.
Reumatol Clin. 2011 Jan-Feb;7(1):68-71. doi: 10.1016/j.reuma.2009.09.010. Epub 2009 Dec 31.
Rheumatoid arthritis is an autoimmune disease of multifactorial etiology characterized by inflammation of the joints and presence of autoantibodies directed against multiple autoantigens. Recently the study of the anti-citrullinated protein antibodies (ACP) has acquired great interest due to its high specificity and sensitivity for diagnosis, in addition to which it has shown to be a predictor of severity in patients with rheumatoid arthritis, suggesting an important participation in the pathogenesis of the disease.
类风湿性关节炎是一种病因多因素的自身免疫性疾病，其特征为关节炎症以及存在针对多种自身抗原的自身抗体。近来，抗瓜氨酸化蛋白抗体（ACP）的研究备受关注，因为它对诊断具有高特异性和敏感性，此外，它已被证明是类风湿性关节炎患者病情严重程度的一个预测指标，这表明它在该疾病的发病机制中起着重要作用。
