Meriño-Ibarra Erardo, Delgado Beltrán Concepción
Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.
Reumatol Clin. 2011 Jul-Aug;7(4):262-6. doi: 10.1016/j.reuma.2010.11.017. Epub 2011 May 4.
Rheumatoid arthritis is a disease that is highly prevalent in women of childbearing age. A review is done about the characteristics of the placental barrier, the passage of drugs through it and the use of drugs during pregnancy: those which are potentially safe drugs, those drugs that can only be used if there is a life threatening condition for the mother, drugs that are contraindicated and those with insufficient data on safety and therefore should be avoided, the latter group comprises biological drugs. Also a review is done about the use of drugs during lactation, a period that a flare of rheumatoid arthritis can occur.
类风湿性关节炎是一种在育龄女性中高度流行的疾病。本文综述了胎盘屏障的特征、药物通过胎盘屏障的情况以及孕期用药：包括潜在安全的药物、仅在母亲有生命危险时才能使用的药物、禁忌药物以及安全性数据不足因而应避免使用的药物（后一组包括生物药物）。此外，还综述了哺乳期（类风湿性关节炎可能发作的时期）的用药情况。
