Department of Diagnostic and Interventional Radiology, University Hospital of Tuebingen, Hoppe-Seyler-Str. 3, 72076 Tuebingen, Germany.
Eur J Radiol. 2012 Oct;81(10):2853-9. doi: 10.1016/j.ejrad.2011.06.047. Epub 2011 Jul 26.
To evaluate intraobserver and interobserver agreement of manually encompassed lung lesions for perfusion measurements using volume-perfusion computed tomography (VPCT).
Institutional review board approval and informed consent were obtained. HIPAA guidelines were followed. A 65-s dynamic study was acquired with scan parameters 80 kV, 60 mAs (80 mAs for patients ≥ 70 kg), 128 × 0.6mm collimation. Blood flow (BF), blood volume (BV) and K(trans) parameters were determined by syngo volume perfusion CT body with 88 lesions analyzed retrospectively.
Within-subject coefficients of variation for intraobserver agreement (range 6.59-12.82%) were superior to those for interobserver agreement (range 21.75-38.30%). Size-dependent analysis revealed lower agreements for lesions <4 cm as compared to larger lesions. Additionally, agreements of the upper, middle and lower lung zones were different.
Intraobserver agreement was substantial for VPCT lung cancer perfusion measurements encouraging the use for tumor characterization and therapy response monitoring. Interobserver agreement is limited and unexperienced readers should be trained before using this new method.
评估使用容积灌注 CT（VPCT）手动勾画肺病变进行灌注测量的观察者内和观察者间一致性。
获得机构审查委员会批准和知情同意。遵循 HIPAA 指南。使用扫描参数 80kV、60mAs（体重≥70kg 患者为 80mAs）、128×0.6mm 准直器进行 65s 动态研究。通过 syngo volume perfusion CT body 确定血流量（BF）、血容量（BV）和 K(trans)参数，对 88 个病变进行回顾性分析。
观察者内一致性的组内变异系数（范围 6.59-12.82%）优于观察者间一致性（范围 21.75-38.30%）。与较大病变相比，<4cm 的病变的一致性较低。此外，肺上、中、下区的一致性也不同。
VPCT 肺癌灌注测量的观察者内一致性很高，这鼓励将其用于肿瘤特征和治疗反应监测。观察者间一致性有限，在使用这种新方法之前，应培训无经验的读者。
