Johns Hopkins University School of Medicine, Department of Medicine, Baltimore, MD 21205, USA.
J Virol. 2011 Oct;85(19):10399-403. doi: 10.1128/JVI.05409-11. Epub 2011 Jul 27.
Circulating HIV-1-infected monocytes have been identified in patients on highly active antiretroviral therapy and may represent an important barrier to viral eradication. The nature of these cells in HIV-1-infected patients who maintain undetectable viral loads and preserved CD4(+) T cell counts without antiretroviral therapy (known as elite controllers or elite suppressors [ES]) is unknown. We describe here infrequent recovery of proviral HIV-1 DNA from circulating monocytes relative to CD4(+) T cells in ES, despite permissiveness of these cells to HIV-1 viral entry ex vivo. Thus, monocytes do not appear to be a major reservoir of HIV-1 in ES.
在接受高效抗逆转录病毒治疗的患者中已经发现了循环感染 HIV-1 的单核细胞，它们可能是病毒清除的一个重要障碍。在未经抗逆转录病毒治疗但能保持病毒载量不可检测和 CD4(+)T 细胞计数正常（称为精英控制者或精英抑制者[ES]）的 HIV-1 感染者中，这些细胞的性质尚不清楚。我们在这里描述了，尽管这些细胞允许 HIV-1 病毒体外进入，但在 ES 中从循环单核细胞中回收前病毒 HIV-1 DNA 的频率相对较低，而 CD4(+)T 细胞中回收的频率较高。因此，单核细胞似乎不是 ES 中 HIV-1 的主要储存库。
