Balink Hans, Hut Evelien, Pol Thomas, Flokstra Freerk-Jan, Roef Mark
Department of Nuclear Medicine, Medical Centre Leeuwarden, Leeuwarden, The Netherlands.
J Nucl Med Technol. 2011 Sep;39(3):185-9. doi: 10.2967/jnmt.110.076489. Epub 2011 Jul 27.
Patients prepared by the generally used fasting protocol show variable myocardial (18)F-FDG uptake, which may result in difficult interpretation of mediastinal (18)F-FDG uptake. This retrospective study described the effect of a 1-d fat-allowed, carbohydrate-restricted diet on myocardial (18)F-FDG uptake.
The study included 100 patients on a carbohydrate-restricted diet from the Medical Center Leeuwarden and 100 patients on an unrestricted diet from the University Medical Center of Utrecht. A visual uptake scale was used, with category 0 indicating myocardial uptake less than liver uptake, category 1 indicating myocardial uptake comparable to liver uptake, and category 2 indicating myocardial uptake considerably higher than liver uptake.
After a carbohydrate-restricted diet, 68% of patients had a homogeneously low myocardial uptake of (18)F-FDG (category 0), 14% had moderate myocardial uptake (category 1), and 18% had homogeneously intense myocardial uptake (category 2). Without a carbohydrate-restricted diet, 69% of patients showed a homogeneously intense myocardial uptake (category 2), 16% a moderate myocardial uptake (category 1), and 15% a homogeneously low myocardial uptake (category 0).
A fat-allowed, carbohydrate-restricted diet starting the day before (18)F-FDG administration suppresses myocardial (18)F-FDG uptake satisfactorily.
采用常用禁食方案准备的患者心肌（18）F-FDG摄取存在差异，这可能导致纵隔（18）F-FDG摄取的解读困难。这项回顾性研究描述了1天允许脂肪、限制碳水化合物饮食对心肌（18）F-FDG摄取的影响。
该研究纳入了来自吕伐登医疗中心的100例接受碳水化合物限制饮食的患者以及来自乌得勒支大学医学中心的100例饮食不受限制的患者。采用视觉摄取量表，0级表示心肌摄取低于肝脏摄取，1级表示心肌摄取与肝脏摄取相当，2级表示心肌摄取显著高于肝脏摄取。
在接受碳水化合物限制饮食后，68%的患者心肌（18）F-FDG摄取均匀较低（0级），14%的患者心肌摄取中等（1级），18%的患者心肌摄取均匀强烈（2级）。在未进行碳水化合物限制饮食的情况下，69%的患者心肌摄取均匀强烈（2级），16%的患者心肌摄取中等（1级），15%的患者心肌摄取均匀较低（0级）。
在（18）F-FDG给药前一天开始的允许脂肪、限制碳水化合物饮食可令人满意地抑制心肌（18）F-FDG摄取。
