Erdoğan Aşkın, Yilmaz Uğur
Başkent University, Faculty of Medicine, Department of astroenterology, Alanya, Antalya, Turkey.
Turk J Gastroenterol. 2011;22(2):134-8. doi: 10.4318/tjg.2011.0181.
BACKGROUND/AIMS: Helicobacter pylori-associated corpus atrophy and autoimmune gastric atrophy share similar histopathologic and clinical aspects. In our study, the relation between Helicobacter pylori and autoimmune gastritis was investigated.
Eighty-two consecutive histologically and serologically Helicobacter pylori-positive and 96 Helicobacter pylori-negative patients were enrolled in the study. All patients underwent diagnostic upper esophagogastroduodenal endoscopy. Three biopsy specimens from the antrum and corpus greater curvature were obtained for histologic evaluation. Serum samples were collected for detection of anti-parietal cell antibody, anti-Helicobacter pylori IgG and vitamin B12. Statistical analyses were determined with Student t-test and chi-square test. Statistical significance was determined with a p-value <0.05.
Of 82 Helicobacter pylori-positive patients, 45 were female and 36 were male, with a mean age 45.1 ± 15.1. There was no significant difference in age, gender and corpus atrophy between the Helicobacter pylori-positive and -negative groups. Eleven Helicobacter pylori-positive patients (13.4%) and 14 (14.6%) Helicobacter pylori-negative patients were positive for anti-parietal cell antibody; the difference between the two groups was not statistically significant (p>0.05). Differences in esophagogastroduodenal endoscopy findings, antrum and corpus inflammation, antrum and corpus atrophy, and vitamin B12 levels were found to be insignificant between parietal cell antibody-positive and -negative groups (p>0.05).
We did not find any relation between Helicobacter pylori infection and anti-parietal cell antibody, a marker of autoimmune gastritis. Long-term follow-up of Helicobacter pylori-infected patients and also determination of the relation between eradication of Helicobacter pylori and autoimmune atrophic gastritis are needed.
背景/目的：幽门螺杆菌相关的胃体萎缩与自身免疫性胃萎缩在组织病理学和临床方面有相似之处。在我们的研究中，对幽门螺杆菌与自身免疫性胃炎之间的关系进行了调查。
连续纳入82例组织学和血清学检查幽门螺杆菌阳性患者以及96例幽门螺杆菌阴性患者。所有患者均接受诊断性上消化道食管胃十二指肠内镜检查。从胃窦和胃体大弯处获取3份活检标本进行组织学评估。采集血清样本检测抗壁细胞抗体、抗幽门螺杆菌IgG和维生素B12。采用Student t检验和卡方检验进行统计分析。以p值<0.05确定统计学显著性。
82例幽门螺杆菌阳性患者中，女性45例，男性36例，平均年龄45.1±15.1岁。幽门螺杆菌阳性组和阴性组在年龄、性别和胃体萎缩方面无显著差异。11例（13.4%）幽门螺杆菌阳性患者和14例（14.6%）幽门螺杆菌阴性患者抗壁细胞抗体呈阳性；两组之间的差异无统计学意义（p>0.05）。壁细胞抗体阳性组和阴性组在食管胃十二指肠内镜检查结果、胃窦和胃体炎症、胃窦和胃体萎缩以及维生素B12水平方面的差异均无统计学意义（p>0.05）。
我们未发现幽门螺杆菌感染与自身免疫性胃炎标志物抗壁细胞抗体之间存在任何关联。需要对幽门螺杆菌感染患者进行长期随访，并确定根除幽门螺杆菌与自身免疫性萎缩性胃炎之间的关系。
