[放射性核素治疗中临床剂量测定的技术方法学方面]

[Technical methodologic aspects of clinical dosimetry in radionuclide therapy].

作者信息

Denisenko O N, Ivanov V N, Drozdovskiĭ B Ia, Nikulin Iu P, Tiatte E G, Ivanova L F, Parshin V S

出版信息

Med Radiol (Mosk). 1990 Feb;35(2):48-52.

Abstract

The paper is devoted to the solution of problems related to clinical dosimetry in radiation therapy with open radionuclides, i.e. technical methodological problems of measurement of an absorbed therapeutic dose of radiation in targets in volume distribution of a radionuclide. The developed methods and means of measurement include a large activity radiometer for measuring therapeutic and diagnostic activities, a topometric ultrasound unit (Aloka) and software. The main features of the method were illustrated on a clinical example of the assessment of an absorbed therapeutic dose of 131I radiation in thyroid tissue during therapy of patients with thyrotoxicosis. The accuracy of the method was assessed.

摘要

本文致力于解决与开放放射性核素放射治疗中临床剂量测定相关的问题，即测量放射性核素在靶区体积分布中辐射吸收治疗剂量的技术方法问题。所开发的测量方法和手段包括用于测量治疗和诊断活度的大活度辐射计、体表超声装置（阿洛卡）及软件。通过一个临床实例说明了该方法的主要特点，该实例为评估甲状腺毒症患者治疗期间甲状腺组织中¹³¹I辐射吸收治疗剂量。对该方法的准确性进行了评估。