Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536-0509, USA.
J Zhejiang Univ Sci B. 2011 Aug;12(8):624-8. doi: 10.1631/jzus.B1101002.
Angiotensin II (AngII) is the primary bioactive peptide of the renin angiotensin system that plays a critical role in many cardiovascular diseases. Subcutaneous infusion of AngII into mice induces the development of abdominal aortic aneurysms (AAAs). Like human AAAs, AngII-induced AAA tissues exhibit progressive changes and considerable heterogeneity. This complex pathology provides an impediment to the quantification of aneurysmal tissue composition by biochemical and immunostaining techniques. Therefore, while the mouse model of AngII-induced AAAs provides a salutary approach to studying the mechanisms of the evolution of AAAs in humans, meaningful interpretation of mechanisms requires consideration of the heterogeneous nature of the diseased tissue.
血管紧张素 II（AngII）是肾素-血管紧张素系统的主要生物活性肽，在许多心血管疾病中发挥着关键作用。将 AngII 皮下输注到小鼠体内会诱导腹主动脉瘤（AAA）的发展。与人类的 AAA 一样，AngII 诱导的 AAA 组织表现出进行性变化和相当大的异质性。这种复杂的病理学为通过生化和免疫染色技术定量动脉瘤组织成分带来了阻碍。因此，虽然 AngII 诱导的 AAA 小鼠模型为研究人类 AAA 演变的机制提供了有益的方法，但要对机制进行有意义的解释，就需要考虑病变组织的异质性。
