Einarsson G, Grimby G, Stålberg E
Department of Rehabilitation Medicine, Gothenburg University, Sweden.
Muscle Nerve. 1990 Feb;13(2):165-71. doi: 10.1002/mus.880130214.
Patients with prior poliomyelitis may experience muscle function deterioration decades after onset of disease. The present study is aimed at describing electromyographic and morphometric evidence of muscular compensation and of on-going muscular instability. Ten subjects 42-62 years of age with onset of polio 25-52 years earlier were studied with macro EMG, single-fiber EMG (SFEMG), muscle strength measurement, and morphometrical analysis of muscle biopsies from the vastus lateralis muscle. SFEMG revealed increased fiber density (FD) and large macro-MUP potentials indicating pronounced reinnervation as compensation to loss of motor neurons. From electrophysiological data of motor unit size, morphometric measures of fiber size, and muscle strength data, the minimal degree of motor neuron loss was estimated to be greater than 70%.
曾患小儿麻痹症的患者在疾病发作数十年后可能会出现肌肉功能衰退。本研究旨在描述肌肉代偿及持续肌肉不稳定的肌电图和形态学证据。对10名年龄在42 - 62岁之间、25 - 52年前患小儿麻痹症的受试者进行了研究，采用了宏肌电图、单纤维肌电图（SFEMG）、肌肉力量测量以及对股外侧肌肌肉活检进行形态学分析。单纤维肌电图显示纤维密度（FD）增加以及巨大的宏运动单位电位（macro - MUP），表明存在明显的神经再支配现象，作为对运动神经元丧失的代偿。根据运动单位大小的电生理数据、纤维大小的形态学测量以及肌肉力量数据，估计运动神经元丧失的最小程度大于70%。
