Department of Pediatric Neurology, Hospital Infantil Universitario Niño Jesús, Avd. Menéndez Pelayo 65, 28009 Madrid, Spain.
Eur J Paediatr Neurol. 2012 Mar;16(2):200-2. doi: 10.1016/j.ejpn.2011.06.007. Epub 2011 Jul 28.
Antiepileptic hypersensitivity syndrome (AHS) is a potentially life-threatening syndrome in pediatric cases. It is associated with aromatic anticonvulsivant drugs and others antibiotics with or without associated reactivation of virus. The pathogenesis of the process is not clear. Clinical feature of this syndrome include cutaneous reactions, fever and lymphadenopathies, but different organs can be involved. In laboratory analyses we can find leucocytosis, eosinophilia, and increase in transaminase levels. Significant elevation of procalcitonin (PCT) has been described in two adults patients. This study we report two cases of a 14-year-old male and a 13-year-old female with a AHS and a high level of the PCT. These are the first cases described in pediatric age. Establishing a diagnosis of AHS is important to avoid the use of the involved drug. The treatment is based on the withdrawal of the drugs that are supposed and if there is no improvement or a deterioration of the patient, the use of systemic corticosteroids is often useful.
抗癫痫药物过敏综合征（AHS）是儿科病例中一种潜在的危及生命的综合征。它与芳香族抗惊厥药物和其他抗生素有关，也与病毒的重新激活有关。该过程的发病机制尚不清楚。该综合征的临床特征包括皮肤反应、发热和淋巴结病，但也可能涉及不同的器官。在实验室分析中，我们可以发现白细胞增多、嗜酸性粒细胞增多和转氨酶水平升高。已有两名成年患者描述了降钙素原（PCT）显著升高的情况。本研究报告了两例 14 岁男性和 13 岁女性 AHS 患者和高 PCT 的病例。这些是儿科年龄组中首次描述的病例。确定 AHS 的诊断很重要，以避免使用相关药物。治疗基于停用可疑药物，如果患者没有改善或病情恶化，通常使用全身皮质类固醇是有用的。
