肺炎支原体与缺血性脑卒中风险增加的关联：一项全国性研究。
Association between Mycoplasma pneumonia and increased risk of ischemic stroke: a nationwide study.
机构信息
Department of Medicine, Healthcare and Management Center, Taipei Veterans General Hospital, and National Yang-Ming University, No 201, Sec 2, Shih-Pai Road, Taipei, Taiwan.
出版信息
Stroke. 2011 Oct;42(10):2940-3. doi: 10.1161/STROKEAHA.110.608075. Epub 2011 Jul 28.
BACKGROUND AND PURPOSE
Infections have been hypothesized to play a role in vascular disease. The association between Mycoplasma pneumoniae (MP) infection and ischemic stroke remained undetermined.
METHODS
A total of 1094 patients with MP infection were enrolled as the study group and compared with 5168 sex-, age-, and comorbidity-matched subjects without MP, to be followed up prospectively from January 2003 to December 2007 for development of ischemic stroke.
RESULTS
During a maximum 5-year follow-up period, 49 patients with ischemic stroke were identified. Subjects with MP infection were significantly associated with increased risk of ischemic stroke compared with controls (1.10% versus 0.72%, respectively; P=0.01). The logrank test showed that patients with MP had significantly higher incidence of stroke development than did those without MP (P=0.046). After Cox model adjustment for risk factors and comorbidities, MP infection was still independently associated with increased risk of stroke (hazard ratio [HR], 2.07; 95% CI, 1.05-4.03).
CONCLUSIONS
We conclude that MP infection is independently associated with risk of subsequent ischemic stroke development.
背景与目的
感染被认为在血管疾病中起作用。肺炎支原体（MP）感染与缺血性卒中之间的关联仍未确定。
方法
共纳入 1094 例 MP 感染患者作为研究组，并与 5168 名性别、年龄和合并症相匹配且无 MP 的患者进行比较，前瞻性随访 2003 年 1 月至 2007 年 12 月，以观察是否发生缺血性卒中。
结果
在最长 5 年的随访期间，发现 49 例缺血性卒中患者。与对照组相比，MP 感染患者发生缺血性卒中的风险显著增加（分别为 1.10%和 0.72%；P=0.01）。对数秩检验显示，MP 组患者的卒中发生率明显高于无 MP 组（P=0.046）。经风险因素和合并症的 Cox 模型调整后，MP 感染仍与卒中风险增加独立相关（风险比 [HR]，2.07；95%可信区间，1.05-4.03）。
结论
我们的结论是，MP 感染与随后发生缺血性卒中的风险独立相关。
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