RUNX1-ETO deregulates the proliferation and growth factor responsiveness of human hematopoietic progenitor cells downstream of the myeloid transcription factor, MYCT1.
作者信息
Liddiard K, Burnett A K, Darley R L, Tonks A
出版信息
Leukemia. 2012 Jan;26(1):177-9. doi: 10.1038/leu.2011.188. Epub 2011 Jul 29.
Abstract
摘要
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RUNX1-ETO deregulates the proliferation and growth factor responsiveness of human hematopoietic progenitor cells downstream of the myeloid transcription factor, MYCT1.RUNX1-ETO使髓系转录因子MYCT1下游的人类造血祖细胞的增殖和生长因子反应性失调。
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Blood. 2011 Apr 14;117(15):e120-30. doi: 10.1182/blood-2010-10-316026. Epub 2011 Jan 13.
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Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia.RUNX1-RUNX1T1介导的正常人祖细胞和急性髓系白血病中的转录失调
Leukemia. 2007 Dec;21(12):2495-505. doi: 10.1038/sj.leu.2404961. Epub 2007 Sep 27.
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MYC levels govern hematopoietic tumor type and latency in transgenic mice.MYC水平决定转基因小鼠的造血肿瘤类型和潜伏期。
Blood. 2006 Jul 15;108(2):653-61. doi: 10.1182/blood-2006-01-0172. Epub 2006 Mar 14.
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Expression of AML1-ETO in human myelomonocytic cells selectively inhibits granulocytic differentiation and promotes their self-renewal.AML1-ETO在人骨髓单核细胞中的表达选择性地抑制粒细胞分化并促进其自我更新。
Leukemia. 2004 Jul;18(7):1238-45. doi: 10.1038/sj.leu.2403396.
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Myc target in myeloid cells-1, a novel c-Myc target, recapitulates multiple c-Myc phenotypes.髓系细胞中的Myc靶点-1，一种新型的c-Myc靶点，概括了多种c-Myc表型。
J Biol Chem. 2002 May 31;277(22):19998-20010. doi: 10.1074/jbc.M200860200. Epub 2002 Mar 21.
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The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation.Gfi-1B原癌蛋白抑制p21WAF1并抑制髓样细胞分化。
Mol Cell Biol. 1998 May;18(5):2462-73. doi: 10.1128/MCB.18.5.2462.
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Cellular characteristics of acute myeloblastic leukemia associated with t(8;21)(q22;q22). The Japanese Cooperative Group of Leukemia/Lymphoma.与t(8;21)(q22;q22)相关的急性髓细胞白血病的细胞特征。日本白血病/淋巴瘤合作组。
Leuk Lymphoma. 1994 Apr;13(3-4):229-34. doi: 10.3109/10428199409056286.
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Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.
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