顺铂预处理增强细胞因子诱导的杀伤细胞的抗肿瘤活性。
Cisplatin pretreatment enhances anti-tumor activity of cytokine-induced killer cells.
机构信息
Department of Medical Oncology, Medical School of Nanjing University, Jinling Hospital, 305 Zhongshan East Road, Nanjing 210002, Jiangsu Province, China.
出版信息
World J Gastroenterol. 2011 Jul 7;17(25):3002-11. doi: 10.3748/wjg.v17.i25.3002.
Abstract
AIM
To investigate whether cisplatin (DDP) enhances the anti-tumor activity of cytokine- induced killer (CIK) cells in a murine colon adenocarcinoma model.
METHODS
Tumor size and weight served as indicators of therapeutic response. Immunohistochemistry was performed to observe intratumoral lymphocyte infiltration and tumor microvessel density. Changes in the percentage of regulatory T (Treg) cells within the spleens of tumor-bearing mice preconditioned with DDP were monitored using flow cytometry.
RESULTS
A marked T cell-dependent, synergistic anti-tumor effect of the combined therapy was observed (1968 ± 491 mm³ vs 3872 ± 216 mm³; P = 0.003). Preconditioning chemotherapy with DDP augmented the infiltration of CD3+ T lymphocytes into the tumor mass and reduced the percentage of both intratumoral and splenic Treg cells.
CONCLUSION
Preconditioning with DDP markedly enhances the efficacy of adoptively transferred CIK cells, providing a potential clinical modality for the treatment of patients with colorectal cancer.
摘要
目的
研究顺铂（DDP）是否增强细胞因子诱导的杀伤（CIK）细胞在小鼠结肠腺癌模型中的抗肿瘤活性。
方法
肿瘤大小和重量作为治疗反应的指标。免疫组织化学用于观察肿瘤内淋巴细胞浸润和肿瘤微血管密度。用流式细胞术监测荷瘤小鼠预先用 DDP 处理后脾脏中调节性 T（Treg）细胞的百分比变化。
结果
观察到联合治疗具有显著的 T 细胞依赖性协同抗肿瘤作用（1968 ± 491 mm³ 对 3872 ± 216 mm³；P = 0.003）。DDP 预处理化疗增强了 CD3+T 淋巴细胞向肿瘤组织的浸润，并降低了肿瘤内和脾脏 Treg 细胞的百分比。
结论
DDP 预处理可显著增强过继转移的 CIK 细胞的疗效，为治疗结直肠癌患者提供了一种潜在的临床方法。
相似文献
1
Cisplatin pretreatment enhances anti-tumor activity of cytokine-induced killer cells.顺铂预处理增强细胞因子诱导的杀伤细胞的抗肿瘤活性。
World J Gastroenterol. 2011 Jul 7;17(25):3002-11. doi: 10.3748/wjg.v17.i25.3002.
2
Preconditioning chemotherapy with cisplatin enhances the antitumor activity of cytokine-induced killer cells in a murine melanoma model.顺铂预处理化疗增强细胞因子诱导的杀伤细胞在小鼠黑色素瘤模型中的抗肿瘤活性。
Cancer Biother Radiopharm. 2012 Apr;27(3):210-20. doi: 10.1089/cbr.2011.1116. Epub 2012 Mar 22.
3
Preconditioning chemotherapy with paclitaxel and cisplatin enhances the antitumor activity of cytokine induced-killer cells in a murine lung carcinoma model.紫杉醇和顺铂预处理化疗增强细胞因子诱导的杀伤细胞在小鼠肺癌模型中的抗肿瘤活性。
Int J Cancer. 2011 Aug 1;129(3):648-58. doi: 10.1002/ijc.25702. Epub 2010 Nov 3.
4
Polysaccharides from Hedyotis diffusa enhance the antitumor activities of cytokine-induced killer cells.白花蛇舌草多糖增强细胞因子诱导的杀伤细胞的抗肿瘤活性。
Biomed Pharmacother. 2019 Sep;117:109167. doi: 10.1016/j.biopha.2019.109167. Epub 2019 Jul 6.
5
Interleukin-15-transferred cytokine-induced killer cells elevated anti-tumor activity in a gastric tumor-bearing nude mice model.白细胞介素-15转导的细胞因子诱导的杀伤细胞在荷胃癌裸鼠模型中增强了抗肿瘤活性。
Cell Biol Int. 2016 Feb;40(2):204-13. doi: 10.1002/cbin.10553. Epub 2015 Nov 15.
6
[Proliferation and cytotoxicity of RetroNectin-activated cytokine-induced killer cells against cisplatin-resistant lung carcinoma cell].[RetroNectin激活的细胞因子诱导杀伤细胞对顺铂耐药肺癌细胞的增殖及细胞毒性作用]
Sheng Wu Gong Cheng Xue Bao. 2008 Aug;24(8):1373-80.
7
Cytokine-induced killer cells induce apoptosis and inhibit the Akt/nuclear factor-κB signaling pathway in cisplatin-resistant human glioma U87MG cells.细胞因子诱导的杀伤细胞诱导顺铂耐药的人胶质瘤U87MG细胞凋亡并抑制Akt/核因子-κB信号通路。
Mol Med Rep. 2015 Nov;12(5):7027-32. doi: 10.3892/mmr.2015.4236. Epub 2015 Aug 21.
8
Repeated cycles of 5-fluorouracil chemotherapy impaired anti-tumor functions of cytotoxic T cells in a CT26 tumor-bearing mouse model.在CT26荷瘤小鼠模型中，5-氟尿嘧啶化疗的重复周期损害了细胞毒性T细胞的抗肿瘤功能。
BMC Immunol. 2016 Sep 20;17(1):29. doi: 10.1186/s12865-016-0167-7.
9
[Effect of Achyranthes bidentata polysaccharides stimulated dendritic cells co-cultured with cytokine induced killer cells against SW480 cells].牛膝多糖刺激树突状细胞与细胞因子诱导的杀伤细胞共培养对SW480细胞的作用
Zhongguo Zhong Yao Za Zhi. 2013 Apr;38(7):1056-60.
10
[Thymoglobulin efficiently expands cytokine-induced killer cells in a clinical-grade culture protocol].[在临床级培养方案中，胸腺球蛋白可有效扩增细胞因子诱导的杀伤细胞]
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Jul;30(7):681-5, 690.
引用本文的文献
1
Immunogenic chemotherapy: great potential for improving response rates.免疫原性化疗：提高缓解率的巨大潜力。
Front Oncol. 2023 Dec 6;13:1308681. doi: 10.3389/fonc.2023.1308681. eCollection 2023.
2
Inhibition of secretory leukocyte protease inhibitor (SLPI) promotes the PUMA-mediated apoptosis and chemosensitivity to cisplatin in colorectal cancer cells.抑制分泌型白细胞蛋白酶抑制剂（SLPI）可促进结直肠癌细胞中PUMA介导的细胞凋亡和顺铂化疗敏感性。
Discov Oncol. 2023 Jan 3;14(1):1. doi: 10.1007/s12672-022-00535-9.
3
NK Cells in the Tumor Microenvironment as New Potential Players Mediating Chemotherapy Effects in Metastatic Melanoma.肿瘤微环境中的自然杀伤细胞作为介导转移性黑色素瘤化疗效果的新潜在因素
Front Oncol. 2021 Oct 12;11:754541. doi: 10.3389/fonc.2021.754541. eCollection 2021.
4
Synergistic effects of low‑dose chemotherapy and T cells in renal cell carcinoma.低剂量化疗与 T 细胞在肾细胞癌中的协同作用。
Oncol Rep. 2020 Sep;44(3):897-908. doi: 10.3892/or.2020.7679. Epub 2020 Jul 7.
5
Crosstalk Between PD-1/PD-L1 Blockade and Its Combinatorial Therapies in Tumor Immune Microenvironment: A Focus on HNSCC.肿瘤免疫微环境中PD-1/PD-L1阻断与其联合疗法之间的相互作用：以头颈部鳞状细胞癌为重点
Front Oncol. 2018 Nov 21;8:532. doi: 10.3389/fonc.2018.00532. eCollection 2018.
6
Adaptive T cell responses induced by oncolytic Herpes Simplex Virus-granulocyte macrophage-colony-stimulating factor therapy expanded by dendritic cell and cytokine-induced killer cell adoptive therapy.溶瘤单纯疱疹病毒-粒细胞巨噬细胞集落刺激因子疗法诱导的适应性T细胞反应通过树突状细胞和细胞因子诱导的杀伤细胞过继性疗法得以扩展。
Oncoimmunology. 2016 Dec 7;6(4):e1264563. doi: 10.1080/2162402X.2016.1264563. eCollection 2017.
7
NaHCO enhances the antitumor activities of cytokine-induced killer cells against hepatocellular carcinoma HepG2 cells.碳酸氢钠增强细胞因子诱导的杀伤细胞对肝癌HepG2细胞的抗肿瘤活性。
Oncol Lett. 2016 Nov;12(5):3167-3174. doi: 10.3892/ol.2016.5112. Epub 2016 Sep 9.
8
Chemotherapy plus dendritic cells co-cultured with cytokine-induced killer cells versus chemotherapy alone to treat advanced non-small-cell lung cancer: A meta-analysis.化疗联合与细胞因子诱导的杀伤细胞共培养的树突状细胞与单纯化疗治疗晚期非小细胞肺癌的Meta分析。
Oncotarget. 2016 Dec 27;7(52):86500-86510. doi: 10.18632/oncotarget.13394.
9
Intralymphatic mRNA vaccine induces CD8 T-cell responses that inhibit the growth of mucosally located tumours.淋巴内mRNA疫苗可诱导CD8 T细胞反应，从而抑制黏膜部位肿瘤的生长。
Sci Rep. 2016 Mar 2;6:22509. doi: 10.1038/srep22509.
10
Cisplatin selectively downregulated the frequency and immunoinhibitory function of myeloid-derived suppressor cells in a murine B16 melanoma model.在小鼠B16黑色素瘤模型中，顺铂选择性地下调了髓源性抑制细胞的频率和免疫抑制功能。
Immunol Res. 2016 Feb;64(1):160-70. doi: 10.1007/s12026-015-8734-1.
本文引用的文献
1
Regulatory T cells: overcoming suppression of T-cell immunity.调节性 T 细胞：克服 T 细胞免疫抑制。
Cancer J. 2010 Jul-Aug;16(4):342-7. doi: 10.1097/PPO.0b013e3181eb336d.
2
Colorectal cancer: national and international perspective on the burden of disease and public health impact.结直肠癌：疾病负担和公共卫生影响的国内外视角。
Gastroenterology. 2010 Jun;138(6):2177-90. doi: 10.1053/j.gastro.2010.01.056.
3
5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity.5-氟尿嘧啶选择性杀死肿瘤相关的髓系来源的抑制性细胞，从而增强 T 细胞依赖性抗肿瘤免疫。
Cancer Res. 2010 Apr 15;70(8):3052-61. doi: 10.1158/0008-5472.CAN-09-3690. Epub 2010 Apr 13.
4
Targeted immunotherapy for colorectal cancer: monoclonal antibodies and immunotoxins.结直肠癌的靶向免疫治疗：单克隆抗体和免疫毒素。
Expert Opin Investig Drugs. 2010 Apr;19 Suppl 1:S67-77. doi: 10.1517/13543781003737668.
5
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.树突状细胞中NLRP3炎性小体的激活诱导针对肿瘤的白细胞介素-1β依赖性适应性免疫。
Nat Med. 2009 Oct;15(10):1170-8. doi: 10.1038/nm.2028. Epub 2009 Sep 20.
6
Treatment in advanced colorectal cancer: what, when and how?晚期结直肠癌的治疗：治疗什么、何时治疗以及如何治疗？
Br J Cancer. 2009 Jun 2;100(11):1704-19. doi: 10.1038/sj.bjc.6605061. Epub 2009 May 12.
7
Suppressive influences in the immune response to cancer.癌症免疫反应中的抑制性影响。
J Immunother. 2009 Jan;32(1):1-11. doi: 10.1097/CJI.0b013e3181837276.
8
FOXP3 expression and overall survival in breast cancer.乳腺癌中FOXP3的表达与总生存期
J Clin Oncol. 2009 Apr 10;27(11):1746-52. doi: 10.1200/JCO.2008.17.9036. Epub 2009 Mar 2.
9
Prospective study of chemotherapy in combination with cytokine-induced killer cells in patients suffering from advanced non-small cell lung cancer.晚期非小细胞肺癌患者化疗联合细胞因子诱导的杀伤细胞的前瞻性研究。
Anticancer Res. 2008 Nov-Dec;28(6B):3997-4002.
10
Immunogenic anti-cancer chemotherapy as an emerging concept.免疫原性抗癌化疗作为一个新兴概念。
Curr Opin Immunol. 2008 Oct;20(5):545-57. doi: 10.1016/j.coi.2008.05.008. Epub 2008 Jun 23.
Zotero 插件