因化疗引起的乙型肝炎病毒再激活导致淋巴瘤患者发生急性肝衰竭而进行的肝移植。
Liver transplantation for acute hepatic failure due to chemotherapy-induced HBV reactivation in lymphoma patients.
机构信息
Department of Abdominal Surgery and Transplantation, CHU de Liège, University of Liège, 4000 Liege, Belgium.
出版信息
World J Gastroenterol. 2011 Jul 7;17(25):3069-72. doi: 10.3748/wjg.v17.i25.3069.
Abstract
Hepatitis B (HBV) reactivation induced by chemotherapy is problem encountered recently in the management of malignant diseases. Chemotherapy-induced HBV reactivation may ultimately lead to terminal acute liver failure. Liver transplantation (LT) currently remains the only definitive treatment option for such cases, but is generally denied to patients suffering from malignancy. Here, the authors describe 2 cases of cancer-free and HBV graft re-infection-free survival after LT performed for terminal liver failure arising from HBV reactivation induced by chemotherapy for advanced stage lymphoma. These 2 cases, and some other reports in the literature, may suggest that patients suffering from hematologic malignancies and terminal liver disease can be considered for LT if the prognosis of their hematologic malignancy is good.
摘要
化疗引起的乙型肝炎病毒（HBV）再激活是恶性肿瘤治疗中最近遇到的问题。化疗诱导的 HBV 再激活可能最终导致终末期急性肝衰竭。肝移植（LT）目前仍然是治疗此类病例的唯一确定性治疗选择，但通常不给予患有恶性肿瘤的患者。在这里，作者描述了 2 例因晚期淋巴瘤化疗诱导的 HBV 再激活导致终末期肝衰竭而行 LT 后无癌症和 HBV 移植物再感染的生存病例。这 2 例病例以及文献中的其他一些报道表明，如果血液恶性肿瘤的预后良好，患有血液恶性肿瘤和终末期肝病的患者可以考虑进行 LT。
相似文献
1
Liver transplantation for acute hepatic failure due to chemotherapy-induced HBV reactivation in lymphoma patients.因化疗引起的乙型肝炎病毒再激活导致淋巴瘤患者发生急性肝衰竭而进行的肝移植。
World J Gastroenterol. 2011 Jul 7;17(25):3069-72. doi: 10.3748/wjg.v17.i25.3069.
2
Urgent liver transplantation for chemotherapy-induced HBV reactivation: a suitable option in patients recently treated for malignant lymphoma.化疗诱导的乙肝病毒再激活后的紧急肝移植：恶性淋巴瘤近期治疗患者的合适选择。
Transplant Proc. 2013 Sep;45(7):2834-7. doi: 10.1016/j.transproceed.2013.03.047.
3
Hepatitis B virus reactivation and role of antiviral prophylaxis in lymphoma patients with past hepatitis B virus infection who are receiving chemoimmunotherapy.乙型肝炎病毒再激活与抗病毒预防在接受化疗免疫治疗的既往乙型肝炎病毒感染淋巴瘤患者中的作用。
Cancer. 2010 Jan 1;116(1):115-21. doi: 10.1002/cncr.24742.
4
Risk and prophylaxis strategy of hepatitis B virus reactivation in patients with lymphoma undergoing chemotherapy with or without rituximab.接受含或不含利妥昔单抗化疗的淋巴瘤患者中乙型肝炎病毒再激活的风险及预防策略
Leuk Lymphoma. 2015 Jun;56(6):1611-8. doi: 10.3109/10428194.2014.964699. Epub 2015 Feb 20.
5
[Therapy-related Virus Reactivation in Lymphoma Patients with Hepatitis B Virus Infection--Review].[乙型肝炎病毒感染淋巴瘤患者的治疗相关病毒再激活——综述]
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016 Feb;24(1):266-70. doi: 10.7534/j.issn.1009-2137.2016.01.051.
6
Reactivation of hepatitis B virus in patients with undetectable HBsAg undergoing chemotherapy for malignant lymphoma or multiple myeloma.接受化疗治疗恶性淋巴瘤或多发性骨髓瘤的 HBsAg 不可检测患者中乙型肝炎病毒再激活。
J Med Virol. 2013 Nov;85(11):1900-6. doi: 10.1002/jmv.23694. Epub 2013 Aug 7.
7
Randomized controlled trial of entecavir prophylaxis for rituximab-associated hepatitis B virus reactivation in patients with lymphoma and resolved hepatitis B.恩替卡韦预防利妥昔单抗相关乙型肝炎病毒再激活的随机对照试验：在淋巴瘤和乙型肝炎已解决的患者中的应用。
J Clin Oncol. 2013 Aug 1;31(22):2765-72. doi: 10.1200/JCO.2012.48.5938. Epub 2013 Jun 17.
8
[Analysis of the prophylactic effect of nucleosides against reactivation of HBV in HBsAg-positive patients with non-hepatic tumors after chemotherapy].[核苷类药物对化疗后非肝肿瘤HBsAg阳性患者HBV再激活的预防作用分析]
Zhonghua Zhong Liu Za Zhi. 2010 Jun;32(6):459-62.
9
[Efficacy of liver transplantation for acute hepatic failure caused by reactivation of hepatitis B virus infection after chemotherapy and radiotherapy for diffuse large B-cell lymphoma].[肝移植治疗弥漫性大B细胞淋巴瘤放化疗后乙型肝炎病毒感染再激活所致急性肝衰竭的疗效]
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2014 Aug;22(4):1005-11. doi: 10.7534/j.issn.1009-2137.2014.04.022.
10
Reactivation of hepatitis B virus following systemic chemotherapy for malignant lymphoma.恶性淋巴瘤全身化疗后乙型肝炎病毒再激活
Int J Hematol. 2009 Jul;90(1):13-23. doi: 10.1007/s12185-009-0359-5. Epub 2009 Jun 23.
引用本文的文献
1
Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies in the targeted therapy era.靶向治疗时代血液系统恶性肿瘤患者乙型肝炎病毒再激活的预防与管理。
World J Gastroenterol. 2023 Sep 7;29(33):4942-4961. doi: 10.3748/wjg.v29.i33.4942.
2
De novo acute hepatitis B in myeloperoxidase-specific anti-neutrophil cytoplasmic autoantibody-related microscopic polyangiitis treated with corticosteroids.在接受皮质类固醇治疗的髓过氧化物酶特异性抗中性粒细胞胞浆自身抗体相关显微镜下多血管炎中发生的新发急性乙型肝炎。
CEN Case Rep. 2013 May;2(1):28-33. doi: 10.1007/s13730-012-0033-2. Epub 2012 Sep 12.
3
Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy.接受抗癌治疗的血液系统恶性肿瘤患者中乙型肝炎病毒再激活的预防与管理
World J Gastroenterol. 2016 Jul 28;22(28):6484-500. doi: 10.3748/wjg.v22.i28.6484.
4
Management of patients with hepatitis B who require immunosuppressive therapy.乙型肝炎患者需要免疫抑制治疗的管理。
Nat Rev Gastroenterol Hepatol. 2014 Apr;11(4):209-19. doi: 10.1038/nrgastro.2013.216. Epub 2013 Nov 19.
5
Management of hepatitis B reactivation in patients receiving cancer chemotherapy.乙型肝炎病毒再激活患者在接受癌症化疗时的管理。
Therap Adv Gastroenterol. 2012 Sep;5(5):359-70. doi: 10.1177/1756283X12450245.
本文引用的文献
1
Living donor liver transplantation for acute hepatic failure caused by reactivation of hepatitis B virus infection after chemotherapy for hematologic malignancy: case reports.血液系统恶性肿瘤化疗后乙肝病毒感染再激活所致急性肝衰竭的活体肝移植：病例报告
Transplant Proc. 2010 Apr;42(3):843-5. doi: 10.1016/j.transproceed.2010.02.038.
2
Fulminant hepatic failure due to chemotherapy-induced hepatitis B reactivation: role of rituximab.化疗诱导的乙型肝炎再激活所致暴发性肝衰竭：利妥昔单抗的作用
Z Gastroenterol. 2010 Feb;48(2):258-63. doi: 10.1055/s-0028-1109782. Epub 2010 Feb 2.
3
Escalated-dose BEACOPP in the treatment of patients with advanced-stage Hodgkin's lymphoma: 10 years of follow-up of the GHSG HD9 study.强化剂量的BEACOPP方案治疗晚期霍奇金淋巴瘤患者：德国霍奇金淋巴瘤研究组HD9研究的10年随访
J Clin Oncol. 2009 Sep 20;27(27):4548-54. doi: 10.1200/JCO.2008.19.8820. Epub 2009 Aug 24.
4
Reactivation of hepatitis B virus following systemic chemotherapy for malignant lymphoma.恶性淋巴瘤全身化疗后乙型肝炎病毒再激活
Int J Hematol. 2009 Jul;90(1):13-23. doi: 10.1007/s12185-009-0359-5. Epub 2009 Jun 23.
5
Effect of prophylactic lamivudine for chemotherapy-associated hepatitis B reactivation in lymphoma: a meta-analysis of published clinical trials and a decision tree addressing prolonged prophylaxis and maintenance.预防性拉米夫定对淋巴瘤化疗相关乙型肝炎再激活的影响：已发表临床试验的荟萃分析及关于长期预防和维持治疗的决策树分析
Haematologica. 2009 Jul;94(7):998-1005. doi: 10.3324/haematol.2009.005819. Epub 2009 May 19.
6
Fatal reactivation of hepatitis B after chemotherapy for lymphoma.淋巴瘤化疗后乙肝病毒致命性再激活
BMJ. 2008 Jul 1;337:a423. doi: 10.1136/bmj.39490.680498.BE.
7
Low recurrence of preexisting extrahepatic malignancies after liver transplantation.肝移植后既往肝外恶性肿瘤的低复发率。
Liver Transpl. 2008 Jun;14(6):789-98. doi: 10.1002/lt.21434.
8
Cadaveric liver transplantation for non-acetaminophen fulminant hepatic failure: a 20-year experience.非对乙酰氨基酚所致暴发性肝衰竭的尸体肝移植：20年经验
World J Gastroenterol. 2007 Mar 7;13(9):1427-30. doi: 10.3748/wjg.v13.i9.1427.
9
Brain edema and intracranial hypertension in fulminant hepatic failure: pathophysiology and management.暴发性肝衰竭中的脑水肿和颅内高压：病理生理学与管理
World J Gastroenterol. 2006 Dec 14;12(46):7405-12. doi: 10.3748/wjg.v12.i46.7405.
10
Fatal reactivation of hepatitis B post-chemotherapy for lymphoma in a hepatitis B surface antigen-negative, hepatitis B core antibody-positive patient: potential implications for future prophylaxis recommendations.一名乙肝表面抗原阴性、乙肝核心抗体阳性的淋巴瘤患者化疗后乙肝致命再激活：对未来预防建议的潜在影响
Leuk Lymphoma. 2005 Jul;46(7):1085-9. doi: 10.1080/10428190500062932.
Zotero 插件