Obolens'ka M Iu, Rodrihes R R, Martseniuk O P
Ukr Biokhim Zh (1999). 2011 Jan-Feb;83(1):5-17.
The paper contains short information concerning the role of folate-related processes in cell metabolism and multiple diseases which are characterized by hyperhomocysteinemia. The authors represent more detailed information about the folate-related processes in human placenta, namely about the content of aminothiols at different allelic variants of placental methylenetetrahydrofolate reductase during the course of physiological pregnancy and preeclampsia. The existing data concerning the expression and catalytic activity of corresponding enzymes are corroborated by the authors' own results that proved for the first time the functional activity of transsulfuration pathway in human placenta. This pathway is activated in placental explants in parallel with down-regulation of proliferation and up-regulation of apoptosis when hyperhomocysteinemia is imitated by high concentration of homocysteine in culture medium. On the whole the presented data point to the importance of placental folate-related processes for its normal function.
该论文包含了有关叶酸相关过程在细胞代谢以及以高同型半胱氨酸血症为特征的多种疾病中的作用的简短信息。作者提供了关于人胎盘叶酸相关过程的更详细信息，即关于生理妊娠和子痫前期过程中胎盘亚甲基四氢叶酸还原酶不同等位基因变体处氨基硫醇的含量。作者自己的结果证实了有关相应酶的表达和催化活性的现有数据，首次证明了转硫途径在人胎盘中的功能活性。当在培养基中用高浓度同型半胱氨酸模拟高同型半胱氨酸血症时，该途径在胎盘外植体中被激活，同时伴随着增殖的下调和细胞凋亡的上调。总体而言，所呈现的数据表明胎盘叶酸相关过程对其正常功能的重要性。
