Kay Christine N, Tarantola Ryan M, Gehrs Karen M, Folk James C, Mahajan Vinit B, Boldt H Culver, Syed Nasreen A, Russell Stephen R
Vitreoretinal Service, Department of Ophthalmology & Visual Sciences, Carver School of Medicine, The University of Iowa, Iowa City, Iowa, USA.
Ophthalmic Surg Lasers Imaging. 2011 Jul-Aug;42(4):292-6. doi: 10.3928/15428877-20110603-04.
In this retrospective case series, the authors report seven cases of bevacizumab-related uveitis that occurred within a 4-month period.
Seven eyes of six patients developed non-infectious uveitis following bevacizumab intravitreal injections in a cohort of 978 consecutive bevacizumab injections.
The mean age of patients was 74.6 years (range: 26 to 92). All patients developed symptom onset within 1 day of injection. Shared signs and symptoms included corneal edema, anterior chamber and vitreous cell, conjunctival injection, ocular pain, and lack of hypopyon. In all patients, visual acuity returned to within one line of baseline acuity. All seven eyes had been previously injected with bevacizumab, with a mean number of antecedent injections of 6.1 (range: 3 to 12).
A cluster of sterile bevacizumab-related uveitic reactions was described in this case series. Acute onset of symptoms, absence of hypopyon, a predominant anterior segment reaction, and prompt improvement on topical steroid therapy are useful clinical features distinguishing this uveitic syndrome from infectious endophthalmitis.
在这个回顾性病例系列中，作者报告了在4个月内发生的7例与贝伐单抗相关的葡萄膜炎病例。
在连续978次玻璃体内注射贝伐单抗的队列中，6例患者的7只眼在注射后发生了非感染性葡萄膜炎。
患者的平均年龄为74.6岁（范围：26至92岁）。所有患者在注射后1天内出现症状。共同的体征和症状包括角膜水肿、前房和玻璃体细胞、结膜充血、眼痛以及无前房积脓。所有患者的视力恢复到基线视力的一行以内。所有7只眼之前均已注射过贝伐单抗，先前注射的平均次数为6.1次（范围：3至12次）。
本病例系列描述了一组与贝伐单抗相关的无菌性葡萄膜炎反应。症状急性发作、无前房积脓、主要为前段反应以及局部类固醇治疗后迅速改善是将这种葡萄膜炎综合征与感染性眼内炎区分开来的有用临床特征。
