Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA.
Annu Rev Cell Dev Biol. 2011;27:585-610. doi: 10.1146/annurev-cellbio-092910-154234. Epub 2011 Jul 21.
Although nearly all mammalian species are diploid, whole-genome duplications occur in select mammalian tissues as part of normal development. Such programmed polyploidization involves changes in the regulatory pathways that normally maintain the diploid state of the mammalian genome. Unscheduled whole-genome duplications, which lead primarily to tetraploid cells, also take place in a substantial fraction of human tumors and have been proposed to constitute an important step in the development of cancer aneuploidy. The origins of these polyploidization events and their consequences for tumor progression are explored in this review.
虽然几乎所有的哺乳动物物种都是二倍体，但全基因组加倍在哺乳动物组织中作为正常发育的一部分发生。这种程序性多倍化涉及到正常维持哺乳动物基因组二倍体状态的调节途径的变化。非计划性的全基因组加倍，主要导致四倍体细胞，也发生在相当一部分人类肿瘤中，并被提议构成癌症非整倍体发展的重要步骤。在这篇综述中探讨了这些多倍化事件的起源及其对肿瘤进展的影响。
