Drug Delivery Technologies and Innovation, Pharmaceutical Sciences Department, Sanofi-aventis, 13 Quai Jules Guesde, 94403 Vitry-sur-Seine, France.
J Hepatol. 2011 Dec;55(6):1461-6. doi: 10.1016/j.jhep.2011.05.039. Epub 2011 Jul 27.
Nanotechnology has been considered for the improved delivery of various therapeutic agents, including drugs and genes. Indeed, liposomes and nanoparticles equipped with homing devices for the targeting of receptors over-expressed on the hepatic tissue have improved the treatment of various liver diseases. In this review, various nanotechnology approaches employed for the treatment/imaging of liver disease, either in preclinical or in clinic are discussed.
纳米技术已被认为可以提高各种治疗剂(包括药物和基因)的递送效率。事实上,装载有针对肝脏组织中过度表达的受体的归巢装置的脂质体和纳米颗粒已经改善了各种肝脏疾病的治疗效果。在这篇综述中,讨论了各种用于治疗/成像肝脏疾病的纳米技术方法,无论是在临床前还是临床阶段。