Department of Neurosurgery, The Johns Hopkins University School of Medicine, Phipps 123, 600 North Wolfe Street, Baltimore, MD 21287, USA.
Neurosurg Clin N Am. 2011 Jul;22(3):385-94, viii. doi: 10.1016/j.nec.2011.04.002. Epub 2011 Jun 8.
Intracranial GCTs are a heterogeneous group of neoplasms most commonly diagnosed in the pediatric population. Germinomas are exquisitely radiosensitive with long-term survival rates in excess of 90% with radiotherapy alone. NGGCTs are associated with a poorer prognosis and are typically treated with a combination of radiation and chemotherapy. Given the young age of these patients, achieving optimal outcomes will ultimately require a careful balance of maximizing disease control while minimizing adverse treatment effects. Here we review the management of intracranial GCTs and discuss the clinical outcomes of patients who undergo treatment for these rare and fascinating tumors.
颅内生殖细胞肿瘤是一组异质性肿瘤，最常见于儿科人群。生殖细胞瘤对放疗高度敏感，单独放疗的长期生存率超过 90%。非生殖细胞瘤性生殖细胞肿瘤预后较差，通常采用放疗和化疗联合治疗。鉴于这些患者年龄较小，最终需要在最大限度地控制疾病的同时，最小化治疗的不良反应，以达到最佳治疗效果。本文回顾了颅内生殖细胞肿瘤的治疗方法，并讨论了接受这些罕见而引人入胜的肿瘤治疗的患者的临床结局。
