Kyank H
Klinik für Gynäkologie und Geburtshilfe des Bereichs Medizin, Wilhelm-Pieck-Universität Rostock.
Zentralbl Gynakol. 1990;112(1):5-10.
Corresponding to the newer literature and based on good own experiences lasting for four decades magnesium sulfate is put out as anticonvulsive drug of first choice in cases of severe preeclampsia and eclampsia. Especially the dosage is explained in connection with the classic schemes of Pritchard and Zuspan, in which a high concentration of magnesium in serum situated in therapeutic range is aspired to without additional sedatives. As standard dose initially 4 g MgSO4, followed by 2 g/h intravenously (in severe cases in the first hours 3 g/h) for continuing serum level applied by infusion pump are recommended. Dihydralazine as most used drug shall be applied by a second pump. Besides some newer results about the effects of magnesium sulfate on mother and child are mentioned.
根据最新文献并基于长达四十年的良好自身经验,硫酸镁被推荐为重度子痫前期和子痫病例的首选抗惊厥药物。特别结合普里查德(Pritchard)和祖斯潘(Zuspan)的经典方案对剂量进行了解释,该方案旨在使血清镁浓度维持在治疗范围内,且无需额外使用镇静剂。推荐的标准剂量为初始静脉注射4g硫酸镁,随后以2g/小时(严重病例在最初几小时为3g/小时)通过输液泵持续输注以维持血清水平。最常用的药物肼屈嗪应由第二个泵给药。此外,还提及了一些关于硫酸镁对母婴影响的最新研究结果。