Radboud University Nijmegen Medical Centre, Department of Psychiatry, Nijmegen, The Netherlands.
J Neurol Sci. 2011 Nov 15;310(1-2):220-4. doi: 10.1016/j.jns.2011.07.007. Epub 2011 Jul 29.
Depression is one of the most common non-motor symptoms of Parkinson's disease (PD) with a large negative impact on the quality of life. Factors such as disease stage, subtype of PD and gender might play an important role in the prevalence of depression, but a large study investigating all these factors in a within-subject design is lacking. Therefore we studied a homogeneous group of 256 Dutch PD patients (60% men, mean age=65.12 (±9.6) years). In total, 36.3% of the subjects had a BDI-score indicative for a minor depression, while 12.9% had a major depression. Notably, only 8.6% of the minor depressed patients and 30.3% of the major depressed patients were taking antidepressants. A higher prevalence of depression was observed in the later stages of the disease. However, this finding was absent in a smaller subsample after correction for cognitive impairment. Our data did not show a difference in the prevalence of depression between the motor subtypes and showed a trend towards higher prevalence of depression in the tremor dominant group. There was no significant difference in the prevalence of depression between men and women. We will discuss the relevance of these results in relation to the findings of other studies.
抑郁是帕金森病（PD）最常见的非运动症状之一，对生活质量有很大的负面影响。疾病阶段、PD 亚型和性别等因素可能在抑郁的患病率中起重要作用，但缺乏一项在同一受试者中研究所有这些因素的大型研究。因此，我们研究了 256 名荷兰 PD 患者（60%为男性，平均年龄=65.12（±9.6）岁）的同质组。共有 36.3%的受试者 BDI 评分提示存在轻度抑郁，而 12.9%存在重度抑郁。值得注意的是，只有 8.6%的轻度抑郁患者和 30.3%的重度抑郁患者正在服用抗抑郁药。在疾病的后期观察到抑郁的患病率更高。然而，在对认知障碍进行校正后，这一发现在较小的亚样本中并不存在。我们的数据没有显示抑郁在运动亚型之间的患病率存在差异，并且在震颤为主的组中抑郁的患病率呈上升趋势。抑郁的患病率在男性和女性之间没有显著差异。我们将根据其他研究的结果讨论这些结果的相关性。
