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[神经肌肉阻滞剂在院前医学中的应用:法国东南部紧急移动服务的实践调查]

[Use of neuromuscular blocking agents in prehospital medicine: practice survey in Emergency Mobile Services of the South-East of France].

作者信息

Chabanne R, Colomb S, Gonzalez D, Perbet S

机构信息

Smur-Samu 63, CHU de Clermont-Ferrand, 58, rue Montalembert, 63000 Clermont-Ferrand, France.

出版信息

Ann Fr Anesth Reanim. 2011 Sep;30(9):636-40. doi: 10.1016/j.annfar.2011.03.019. Epub 2011 Jul 29.

Abstract

OBJECTIVE

To evaluate the use of neuromuscular blocking agents (NMBA) in the French adult Prehospital Emergency Medical Services (PEMS).

STUDY DESIGN

Telephone survey of practices.

MATERIALS AND METHODS

A survey was conducted from April to July 2009 in every PEMS of the South-East of France. A PEMS physician by center was interviewed using a standardized quiz including demographic data, methods of anesthetic induction, use of NMBA and succinylcholine.

RESULTS

All 86 EMS were interviewed. Succinylcholine was used in 98% of cases for rapid sequence induction. Nondepolarizing NMBA were never used by 38%. They were not available in 21% of PEMS. Among the practitioners using them, 79% prescribed them rarely (less than 25% of intubated patients). Nondepolarizing NMBA were prescribed in more than half of cases of patient ventilator asynchrony by 27% of physicians, of ventilator high pressure (23%), of acute status asthmaticus (23%), of suspicion of intracranial hypertension (22%), of refractory hypoxemia (16%), therapeutic hypothermia (10%). Limitations of prescription were essentially little guidance and lack of training. Atracurium and cisatracurium were the most used. The exact dosages were known by only 18% of practitioners. None of the practitioners were performing a monitoring of NMBA.

CONCLUSION

This survey highlights the very frequent use of succinylcholine for rapid sequence induction and low use of nondepolarizing NMBA for selected indications. A training endeavor could be undertaken to improve the use of these anesthetic drugs by prehospital physicians.

摘要

目的

评估法国成人院前急救医疗服务(PEMS)中神经肌肉阻滞剂(NMBA)的使用情况。

研究设计

实践的电话调查。

材料与方法

2009年4月至7月对法国东南部的每个PEMS进行了一项调查。通过标准化测验对每个中心的一名PEMS医生进行访谈,内容包括人口统计学数据、麻醉诱导方法、NMBA和琥珀酰胆碱的使用情况。

结果

共访谈了86个急救医疗服务机构。98%的病例使用琥珀酰胆碱进行快速顺序诱导。38%的机构从未使用过非去极化NMBA。21%的PEMS没有此类药物。在使用非去极化NMBA的从业者中,79%很少开具此类药物(插管患者中使用比例不到25%)。27%的医生在超过一半的患者呼吸机不同步、23%的呼吸机高压、23%的急性哮喘状态、22%的疑似颅内高压、16%的难治性低氧血症、10%的治疗性低温病例中开具非去极化NMBA。处方的局限性主要是指导不足和缺乏培训。阿曲库铵和顺式阿曲库铵是最常用的。只有18%的从业者知道确切剂量。没有从业者对NMBA进行监测。

结论

这项调查突出了琥珀酰胆碱在快速顺序诱导中的频繁使用以及非去极化NMBA在特定适应症中的低使用情况。可以努力开展培训,以改善院前医生对这些麻醉药物的使用。

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