III. Medical Clinic, Department of Pulmonary Medicine, University of Mainz, Maniz, Germany.
Phytomedicine. 2012 Jan 15;19(2):115-21. doi: 10.1016/j.phymed.2011.06.030. Epub 2011 Jul 29.
Aqueous extract of Kalanchoe pinnata (Kp) have been found effective in models to reduce acute anaphylactic reactions. In the present study, we investigate the effect of Kp and the flavonoid quercetin (QE) and quercitrin (QI) on mast cell activation in vitro and in a model of allergic airway disease in vivo. Treatment with Kp and QE in vitro inhibited degranulation and cytokine production of bone marrow-derived mast cells following IgE/FcɛRI crosslinking, whereas treatment with QI had no effect. Similarly, in vivo treatment with Kp and QE decreased development of airway hyperresponsiveness, airway inflammation, goblet cell metaplasia and production of IL-5, IL-13 and TNF. In contrast, treatment with QI had no effect on these parameters. These findings demonstrate that treatment with Kp or QE is effective in treatment of allergic airway disease, providing new insights to the immunomodulatory functions of this plant.
研究发现，马齿苋（Kp）的水提物在减少急性过敏反应的模型中具有疗效。本研究旨在探讨马齿苋和类黄酮槲皮素（QE）、槲皮苷（QI）对体外肥大细胞活化以及体内变应性气道疾病模型的影响。体外实验中，Kp 和 QE 处理可抑制 IgE/FcɛRI 交联后骨髓来源的肥大细胞脱颗粒和细胞因子产生，而 QI 处理则没有这种作用。同样，体内 Kp 和 QE 处理可减少气道高反应性、气道炎症、杯状细胞化生以及白细胞介素-5（IL-5）、白细胞介素-13（IL-13）和肿瘤坏死因子（TNF）的产生。相比之下，QI 处理对这些参数没有影响。这些发现表明，Kp 或 QE 治疗可有效治疗变应性气道疾病，为这种植物的免疫调节功能提供了新的见解。
