Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Cell Metab. 2011 Aug 3;14(2):143-4. doi: 10.1016/j.cmet.2011.07.003.
Reprogramming involves multiple layers of molecular regulation, yet it remains relatively unknown how the cell's metabolism is changing and/or contributing to this process. In this issue of Cell Metabolism, Folmes et al. (2011) demonstrate that reprogramming induces a bioenergetic transition from an oxidative to a glycolytic state, and provide evidence to suggest that these changes may precede pluripotency.
重编程涉及多个层次的分子调控，但细胞代谢如何变化以及/或对此过程做出贡献仍相对未知。在本期《细胞代谢》中，Folmes 等人（2011 年）表明，重编程诱导了从氧化到糖酵解状态的生物能量转变，并提供了证据表明这些变化可能先于多能性。
