University of Rostock, Department of Pneumology, Germany.
J Neuroimmunol. 2011 Sep 15;238(1-2):104-6. doi: 10.1016/j.jneuroim.2011.06.015. Epub 2011 Jul 31.
Anti-platelet treatment is a key therapeutic intervention in patients with cerebrovascular diseases. However, there is no information on its impact on the release of Brain-derived neurotrophic factor (BDNF), which is stored in large amounts in human platelets and essential for neuronal protection and repair. Here, we show that a single oral dose of clopidogrel, but not aspirin, significantly reduced the release of BDNF from platelets in healthy volunteers. These data point, for the first time, to possible differential effects of anti-platelet regimens on neuronal function in patients with cerebrovascular disorders.
抗血小板治疗是脑血管疾病患者的关键治疗干预措施。然而，目前尚无关于其对脑源性神经营养因子 (BDNF) 释放影响的信息，BDNF 在人类血小板中大量储存，对神经元保护和修复至关重要。在这里，我们表明，单次口服氯吡格雷，而不是阿司匹林，可显著减少健康志愿者血小板中 BDNF 的释放。这些数据首次指出，抗血小板治疗方案对脑血管疾病患者的神经元功能可能具有不同的影响。
