Bagrov Ia Iu, Vasil'eva V F, Vorob'eva K P, Gusev G P, Krestinskaia T V
Kardiologiia. 1979 Feb;19(2):80-5.
Circulatory insufficiency in rats was induced by constriction of the thoracic portion of vena cava inferior. Two-three days after the operation renal function was studied and the activity of succinate dehydrogenase and Na+K+-ATPase in the cells of the renal tubules was determined cytochemically. On infusion of 0.9% NaCl solution into the stomach, the filtration in the "caval" rats did not change whereas the excretion of sodium and its concentration in the urine were much lower than in the sham operated rats. At the same time, the activity of Na+K+-ATPase and succinate dehydrogenase in the "caval" rats increased in the cells of the proximal tubule, diminished in Henle's loop, and remained unchanged in the cells of the distal convoluted tubule. Comparison of the results of functional and cytochemical study of the kidneys in caval rats allows the conclusion that intensified proximal reabsorption may be the main cause of antinatriuresis in these animals. The lesser load experienced by the distal segment promotes fuller reabsorption of sodium in this part of the nephron too.
通过结扎下腔静脉胸部来诱导大鼠循环功能不全。术后两到三天研究肾功能，并通过细胞化学方法测定肾小管细胞中琥珀酸脱氢酶和钠钾ATP酶的活性。给“腔静脉结扎”大鼠经胃灌注0.9%氯化钠溶液时，其滤过率未发生变化，但钠排泄量及其尿中浓度远低于假手术大鼠。同时，“腔静脉结扎”大鼠近端小管细胞中钠钾ATP酶和琥珀酸脱氢酶的活性增加，髓袢细胞中活性降低，远曲小管细胞中活性保持不变。对腔静脉结扎大鼠肾脏功能和细胞化学研究结果的比较表明，近端重吸收增强可能是这些动物钠尿排泄减少的主要原因。远曲小管段负荷减轻也促进了该肾单位部分钠的充分重吸收。
