Meng Xianghong, Dong Mei, Wang D I, He Jufang, Yang Caie, Zhu Lei, Sun Minxia
Department of Clinical Laboratory, Chinese PLA 309 Hospital, Beijing, China.
J Chemother. 2011 Aug;23(4):207-10. doi: 10.1179/joc.2011.23.4.207.
In this study we investigated the prevalence of antimicrobial resistance in clinical isolates of Gram-negative bacteria obtained from intensive care units (ICUs) in the People's Liberation Army (PLA) 309 Hospital located in beijing, China. between 2007 and 2010, a total of 1949 isolates of Gram-negative bacteria were collected and tested using an antibiotic susceptibility assay. A marked decrease was observed in the susceptibility of Acinetobacter baumannii to imipenem and amikacin as compared to that described in a previous report in China. Similar results were obtained for Pseudomonas aeruginosa. However, imipenem and amikacin showed strong activity against Escherichia coli and Klebsiella pneumoniae. Overall, the high rates of antimicrobial resistance against ICU pathogens in our hospital indicated a critical condition in Beijing, China. Development of a national control and monitoring system by the government may be an ideal method to solve the present problem of managing infections due to Gram-negative bacterial pathogens.
在本研究中，我们调查了从位于中国北京的解放军309医院重症监护病房（ICU）分离出的革兰氏阴性菌临床菌株中的抗菌药物耐药性流行情况。2007年至2010年期间，共收集了1949株革兰氏阴性菌，并使用抗生素敏感性试验进行检测。与中国之前一份报告中描述的情况相比，观察到鲍曼不动杆菌对亚胺培南和阿米卡星的敏感性显著下降。铜绿假单胞菌也得到了类似结果。然而，亚胺培南和阿米卡星对大肠杆菌和肺炎克雷伯菌显示出较强活性。总体而言，我院ICU病原体的高抗菌药物耐药率表明中国北京的情况严峻。政府建立全国控制和监测系统可能是解决目前革兰氏阴性菌病原体感染管理问题的理想方法。
