Beović B, Kreft S, Seme K, Cizman M
Department of Infectious Diseases, University Medical Centre Ljubljana, Japljeva 2, 1525 Ljubljana, Slovenia.
J Chemother. 2011 Aug;23(4):216-20. doi: 10.1179/joc.2011.23.4.216.
We investigated the effect of ertapenem on carbapenem susceptibility of Pseudomonas aeruginosa. Antibiotic consumption was recorded monthly in defined daily doses (DDD)/100 patient-days in the infectious diseases (ID), abdominal surgery (AS), and surgical intensive care units (SICU) of a teaching hospital from January 2005 to December 2008. Trends of decreased susceptibility of P. aeruginosa were observed in all three units. After the introduction of ertapenem, the number of P. aeruginosa isolates/ 1000 patients-days per month increased in AS and in SICU (p=0.05). The increase in carbapenem non-susceptible isolates/1000 patients-days in the same units was less significant (p=0.07 and p=0.054). Correlations between ertapenem and the carbapenem non-susceptibility for the lagtime of 1 to 6 months ahead gave no significant result. In the SICU, 30% of variability of carbapenem non-susceptibility could be predicted by the consumption of ertapenem. There is no evidence that ertapenem alters the P. aeruginosa susceptibility to carbapenems, but the relationship deserves further observation.
我们研究了厄他培南对铜绿假单胞菌碳青霉烯类药物敏感性的影响。2005年1月至2008年12月期间，在一家教学医院的传染病科（ID）、腹部外科（AS）和外科重症监护病房（SICU），每月以限定日剂量（DDD）/100患者日记录抗生素使用量。在所有三个科室均观察到铜绿假单胞菌敏感性下降的趋势。引入厄他培南后，AS和SICU中每月每1000患者日的铜绿假单胞菌分离株数量增加（p=0.05）。相同科室中每1000患者日碳青霉烯类药物不敏感分离株的增加不太显著（p=0.07和p=0.054）。厄他培南与提前1至6个月的碳青霉烯类药物不敏感性之间的相关性未得出显著结果。在SICU中，碳青霉烯类药物不敏感性30%的变异性可由厄他培南的使用量预测。没有证据表明厄他培南会改变铜绿假单胞菌对碳青霉烯类药物的敏感性，但这种关系值得进一步观察。
