Synthesis and anti-human immunodeficiency virus activity of the skeleton isomers of 3',4'-Di-(O)-(-)-camphanoyl-(+)-khellactone.

作者信息

Nishioka Hiromi, Uesugi Koji, Ueda Norihiro, Kondo Yuka, Tsuji Megumi, Abe Hitoshi, Harayama Takashi, Hamasaki Takayuki, Baba Masanori, Takeuchi Yasuo

机构信息

Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2011;59(8):1075-6. doi: 10.1248/cpb.59.1075.

Optically active structural isomers (1b-f and dst-1b-f) of 3',4'-di-(O)-(-)-camphanoyl-(+)-khellactone (DCK) were synthesized and their anti-human immunodeficiency virus (HIV) activity was investigated. The value of the sensitivity index (SI) of 1b was greater than that of DCK.