帕金森病患者的疲劳：对生活质量的影响。
Fatigue in patients with Parkinson's disease: impact on quality of life.
作者信息
Miwa Hideto, Miwa Takako
机构信息
Department of Neurology, Wakayama Medical University, Japan.
出版信息
Intern Med. 2011;50(15):1553-8. doi: 10.2169/internalmedicine.50.4954. Epub 2011 Aug 1.
OBJECTIVE
To determine the prevalence of fatigue and factors associated with fatigue in patients with Parkinson's disease (PD).
METHODS
Fatigue was evaluated using the PD Fatigue Scale, a self-report questionnaire consisting of 16 statements describing the severity of fatigue symptoms. Patients were also evaluated using the Unified PD Rating Scale, Zung Depression Scale, the Epworth Sleepiness Scale, the PD Questionnaire-39 (PDQ-39) for assessing quality of life (QOL), and the Apathy Scale.
PATIENTS
We examined 46 consecutive outpatients clinically diagnosed with PD, excluding patients with cognitive impairment.
RESULTS
Fatigue was present in 22 (48%) patients. Multiple logistic regression analysis indicated that only QOL-scores and Apathy Scale scores were significant independent variables related to the presence of fatigue.
CONCLUSION
Fatigue is a common symptom in patients with PD, and it is a symptom closely related to impaired QOL.
目的
确定帕金森病（PD）患者疲劳的患病率以及与疲劳相关的因素。
方法
使用帕金森病疲劳量表评估疲劳，这是一份自我报告问卷，由16条描述疲劳症状严重程度的陈述组成。还使用统一帕金森病评定量表、zung抑郁量表、爱泼华嗜睡量表、用于评估生活质量（QOL）的帕金森病问卷-39（PDQ-39）和淡漠量表对患者进行评估。
患者
我们检查了46例临床诊断为PD的连续门诊患者，排除了认知障碍患者。
结果
22例（48%）患者存在疲劳。多因素logistic回归分析表明，只有生活质量评分和淡漠量表评分是与疲劳存在相关的显著独立变量。
结论
疲劳是PD患者的常见症状，并且是一种与生活质量受损密切相关的症状。
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