Yuan Yong-Sheng, Ji Min, Gan Cai-Ting, Sun Hui-Min, Wang Li-Na, Zhang Ke-Zhong
Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
J Pers Med. 2022 May 27;12(6):884. doi: 10.3390/jpm12060884.
The characteristics of interhemispheric resting-state functional connectivity (FC) in Parkinson's disease (PD) with fatigue remain unclear; therefore, we aimed to explore the changes in interhemispheric FC in PD patients with fatigue. Sixteen PD patients with fatigue (PDF), 16 PD patients without fatigue (PDNF) and 15 matched healthy controls (HCs) were enrolled in the retrospective cross-sectional study. We used voxel-mirrored homotopic connectivity (VMHC) to analyze the resting-state functional magnetic resonance imaging (fMRI) data of these subjects. Compared to PDNF, PDF patients had decreased VMHC values in the supramarginal gyri (SMG). Furthermore, the mean VMHC values of the SMG were negatively correlated with the mean fatigue severity scale (FSS/9) scores ( = -0.754, = 0.001). Compared to HCs, PDF patients had decreased VMHC in the SMG and in the opercular parts of the inferior frontal gyri (IFG operc). The VMHC values in the IFG operc and middle frontal gyri (MFG) were notably decreased in PDNF patients compared with HCs. Our findings suggest that the reduced VMHC values within the bilateral SMG may be the unique imaging features of fatigue in PD, and may illuminate the neural mechanisms of fatigue in PD.
帕金森病（PD）伴疲劳患者的半球间静息态功能连接（FC）特征尚不清楚；因此，我们旨在探讨PD伴疲劳患者半球间FC的变化。16例伴疲劳的PD患者（PDF）、16例无疲劳的PD患者（PDNF）和15名匹配的健康对照者（HCs）纳入了这项回顾性横断面研究。我们使用体素镜像同伦连接（VMHC）来分析这些受试者的静息态功能磁共振成像（fMRI）数据。与PDNF相比，PDF患者的缘上回（SMG）VMHC值降低。此外，SMG的平均VMHC值与平均疲劳严重程度量表（FSS/9）评分呈负相关（r = -0.754，P = 0.001）。与HCs相比，PDF患者的SMG以及额下回岛盖部（IFG operc）的VMHC降低。与HCs相比，PDNF患者的IFG operc和额中回（MFG）的VMHC值显著降低。我们的研究结果表明，双侧SMG内VMHC值降低可能是PD疲劳的独特影像学特征，并可能阐明PD疲劳的神经机制。
