Department of Medicine 1, University of Erlangen-Nuremberg, Erlangen, Germany.
Med Sci Monit. 2011 Aug;17(8):CS103-107. doi: 10.12659/msm.881891.
Metastatic insulinoma is a disease associated with a poor life expectancy.
The case of a presently 68 year old female with malignant, metastatic insulinoma is reported. Due to severe clinical symptoms surgical tumor mass reduction was conducted. Furthermore the patient underwent a chemotherapy using streptozotocine and fluorouracil. After two years without any symptoms, the remaining hepatic metastases increased in size and again hypoglycemias occurred. To reachieve an asymptomatic state and further reduction in tumor mass, the decision was made for transarterial chemoembolization with streptozotocine. After the first treatment the patient was hypoglycemia - free for 3 months, after another more extensive chemoembolization the patient is presently symptom free for 8 months.
Since the diagnosis of extended disease was established, the patient has survived for 36 months. We regard this as the result of a multimodal approach and the extensive use of local tumor therapy. The different therapeutic options for local tumor therapy are reported and discussed.
转移性胰岛素瘤是一种预后不良的疾病。
报告了一例目前 68 岁的女性患有恶性转移性胰岛素瘤。由于严重的临床症状，进行了手术肿瘤减积。此外，患者接受了链脲佐菌素和氟尿嘧啶化疗。两年后无症状，残留肝转移灶增大，再次发生低血糖。为了达到无症状状态和进一步减少肿瘤体积，决定进行经动脉化疗栓塞术，使用链脲佐菌素。第一次治疗后，患者 3 个月内无低血糖，再次进行更广泛的化疗栓塞后，患者目前已无症 8 个月。
自诊断为晚期疾病以来，患者已存活 36 个月。我们认为这是多模式治疗和广泛使用局部肿瘤治疗的结果。报告并讨论了局部肿瘤治疗的不同治疗选择。
