Wang Y, Li J, Guo X, Zhao D, Hu D, Wei Y, Hou L, Xu Y, Ma Y
Department of Cardiology, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai, China.
Int Angiol. 2011 Oct;30(5):451-7.
The study was designed to investigate the relationship between ankle-brachial index (ABI) and carotid intima-media thickness (IMT), and provide scientific basis for primary and secondary prevention of atherosclerotic diseases.
Participants were recruited for this investigation from Inner Mongolia in China through cluster multistage and random sampling. ABI and carotid-IMT were measured for each subject. Periphery arterial disease (PAD) was defined as an ABI≤0.9 in either leg. ABI values were divided into eight groups at every 0.05, and three carotid-IMT measures were compared among groups separately using analysis of variance (ANOVA) and multivariate linear regression analyses.
The results indicated that the prevalence of PAD among 1236 participants was 1.9%. The average common carotid IMT was 0.70±0.21 mm, internal carotid IMT 0.77±0.24 mm, and carotid artery bifurcation IMT 0.78±0.25 mm. A U-shaped relationship was observed that the values of common carotid, carotid artery bifurcation, and internal carotid arteries IMT were decreased at first then increased as ABI values increased. The U-shaped relationship between ABI and three carotid-IMT measures were remained after adjusting for covariates.
The data suggests that carotid IMT values are correlated with ABI values in a U-shaped curve. Increased carotid IMT is correlated with the high prevalence of PAD in population of Inner Mongolia in China.
本研究旨在探讨踝臂指数（ABI）与颈动脉内膜中层厚度（IMT）之间的关系，为动脉粥样硬化疾病的一级和二级预防提供科学依据。
通过整群多级随机抽样从中国内蒙古招募参与者进行本调查。对每位受试者测量ABI和颈动脉IMT。外周动脉疾病（PAD）定义为任一腿部的ABI≤0.9。ABI值以0.05为间隔分为八组，分别使用方差分析（ANOVA）和多元线性回归分析比较三组颈动脉IMT测量值。
结果表明，1236名参与者中PAD的患病率为1.9%。颈总动脉平均IMT为0.70±0.21mm，颈内动脉IMT为0.77±0.24mm，颈动脉分叉处IMT为0.78±0.25mm。观察到一种U型关系，即随着ABI值增加，颈总动脉、颈动脉分叉处和颈内动脉的IMT值先降低后升高。在调整协变量后，ABI与三种颈动脉IMT测量值之间的U型关系仍然存在。
数据表明，颈动脉IMT值与ABI值呈U型曲线相关。颈动脉IMT增加与中国内蒙古人群中PAD的高患病率相关。
