一种高效微波辅助合成新型若丹宁衍生物作为潜在HIV-1和JSP-1抑制剂的方法。
An efficient microwave assisted synthesis of novel class of Rhodanine derivatives as potential HIV-1 and JSP-1 inhibitors.
作者信息
Kamila Sukanta, Ankati Haribabu, Biehl Edward R
机构信息
Southern Methodist University, Department of, Chemistry, Dallas, TX, 75275.
出版信息
Tetrahedron Lett. 2011 Aug 24;52(34):4375-4377. doi: 10.1016/j.tetlet.2011.05.114.
Abstract
(Z)-5-(2-(1H-Indol-3-yl)-2-oxoethylidene)-3-phenyl-2-thioxothiazolidin-4-one (7a-q) derivatives have been synthesized by the condensation reaction of 3-phenyl-2-thioxothiazolidin-4-ones (3a-h) with suitably substituted 2-(1H-indol-3-yl)-2-oxoacetaldehyde (6a-d) under microwave condition. The thioxothiazolidine-4-ones were prepared from corresponding aromatic amines (1a-e) and di-(carboxymethyl)-trithiocarbonyl (2). The aldehydes (6a-h) were synthesized from the corresponding acidchlorides (5a-d) using HSnBu(3).
摘要
通过3-苯基-2-硫代噻唑烷-4-酮（3a-h）与适当取代的2-（1H-吲哚-3-基）-2-氧代乙醛（6a-d）在微波条件下缩合反应，合成了（Z）-5-（2-（1H-吲哚-3-基）-2-氧代亚乙基）-3-苯基-2-硫代噻唑烷-4-酮（7a-q）衍生物。硫代噻唑烷-4-酮由相应的芳香胺（1a-e）和二（羧甲基）三硫代羰基（2）制备。醛（6a-h）由相应的酰氯（5a-d）使用三丁基氢化锡（HSnBu(3)）合成。
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