Savolainen Johannes, Alenius Harri, Renkonen Risto
Turun yliopisto, kliininen laitos ja TYKS:n allergiayksikkö, PL 52, 20521 Turku.
Duodecim. 2011;127(12):1289-95.
According to established view, the underlying factor in allergic immune response is imbalance between the number and function of allergen-specific CD4+ lymphocytes. In atopic allergy, type 2 helper T lymphocytes (Th2 cells) are elevated in relation to regulatory T lymphocytes (Treg cells). In healthy subjects the ratio is vice versa. It seems that tolerance generated through allergen-specific Treg cells is the immunologic reaction mode towards allergens in healthy non-atopic subjects. It has been found that hyposensitization will correct the imbalance of Th2 and Treg cells and restore the normal immune response to allergens.
根据既定观点，过敏性免疫反应的潜在因素是过敏原特异性CD4+淋巴细胞数量与功能之间的失衡。在特应性过敏中，2型辅助性T淋巴细胞（Th2细胞）相对于调节性T淋巴细胞（Treg细胞）数量增加。在健康受试者中，比例则相反。似乎通过过敏原特异性Treg细胞产生的耐受性是健康非特应性受试者对过敏原的免疫反应模式。已经发现，减敏疗法将纠正Th2和Treg细胞的失衡，并恢复对过敏原的正常免疫反应。
