海葵毒素 CTX3C 的 HIJKLM 环系的会聚合成。
Convergent synthesis of the HIJKLM ring system of ciguatoxin CTX3C.
机构信息
Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530, Japan.
出版信息
Org Lett. 2011 Sep 2;13(17):4704-7. doi: 10.1021/ol2019136. Epub 2011 Aug 1.
PMID:21805971
Abstract
The HIJKLM ring system of ciguatoxin CTX3C was synthesized in a convergent manner. The key steps were a conjugate addition/alkylation sequence, spiroacetalization, intramolecular allylation, ring-closing metathesis, and hydrogenation to form the 36-α-methyl substituent.
摘要
石房蛤毒素 CTX3C 的 HIJKLM 环系采用汇聚方式合成。关键步骤包括共轭加成/烷基化序列、螺缩酮化、分子内烯丙基化、环 closing metathesis 和氢化形成 36-α-甲基取代基。
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