Karwatowska-Prokopczuk E, Wennmalm A
Department of Clinical Physiology, Medical Centre of Postgraduate Education, Warsaw, Poland.
Clin Physiol. 1990 Mar;10(2):113-21. doi: 10.1111/j.1475-097x.1990.tb00245.x.
The vascular endothelium is not merely a passive physical barrier between the blood and the tissue surrounding the blood vessel, but may actively participate in key processes of metabolic, secretory, and vasoregulatory character. In addition, the endothelium plays an important role in the control of platelet activation. Under certain conditions endothelial cells have been shown to produce powerful vasodilators, like endothelium-derived relaxing factor (EDRF) and prostacyclin (GPI2), and vasoconstrictors like endothelium-derived constricting factor (EDCF) and endothelin (ET) (Griffith et al., 1988; Vanhoutte & Katusic, 1988). In contrast to the extensive studies performed to characterize the actions and nature of EDRF, recently identified chemically as nitric oxide (Moncada et al., 1988), relatively little is known about EDCF(s). This paper reviews recent data on EDCF, with special emphasis on the newly discovered vasoconstrictor peptide, endothelin (ET).
血管内皮不仅仅是血液与血管周围组织之间的被动物理屏障，还可能积极参与代谢、分泌和血管调节特性的关键过程。此外，内皮在控制血小板活化方面发挥着重要作用。在某些条件下，内皮细胞已被证明能产生强大的血管舒张剂，如内皮源性舒张因子（EDRF）和前列环素（GPI2），以及血管收缩剂，如内皮源性收缩因子（EDCF）和内皮素（ET）（格里菲斯等人，1988年；万霍特和卡图西克，1988年）。与为表征EDRF的作用和性质而进行的广泛研究相比，EDRF最近被化学鉴定为一氧化氮（蒙卡达等人，1988年），而关于EDCF的了解相对较少。本文综述了有关EDCF的最新数据，特别强调了新发现的血管收缩肽内皮素（ET）。
