Development of refractory anemia with ring sideroblasts associated with thrombocytosis from pre-existing refractory anemia with ring sideroblasts through acquisition of Jak2 V617F mutation.
作者信息
Lu Chuanyi M, Zhou Lukun, Wang Endi, Feng Sizhou, Sebastian Siby, Behler Caroline
出版信息
Leuk Lymphoma. 2011 Dec;52(12):2405-7. doi: 10.3109/10428194.2011.597907. Epub 2011 Aug 1.
PMID:21806348
Abstract
摘要
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Development of refractory anemia with ring sideroblasts associated with thrombocytosis from pre-existing refractory anemia with ring sideroblasts through acquisition of Jak2 V617F mutation.伴有环形铁粒幼细胞的难治性贫血伴血小板增多症从既往存在的伴有环形铁粒幼细胞的难治性贫血通过获得Jak2 V617F突变发展而来。
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2
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Clinical features and course of refractory anemia with ring sideroblasts associated with marked thrombocytosis.伴有显著血小板增多的难治性环形铁幼粒细胞性贫血的临床特征和病程。
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JAK2V617F mutation status identifies subtypes of refractory anemia with ringed sideroblasts associated with marked thrombocytosis.JAK2V617F突变状态可识别伴有显著血小板增多的环形铁粒幼细胞难治性贫血的亚型。
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Prognostic interaction between thrombocytosis and JAK2 V617F mutation in the WHO subcategories of myelodysplastic/myeloproliferative disease-unclassifiable and refractory anemia with ringed sideroblasts and marked thrombocytosis.血小板增多症与JAK2 V617F突变在世界卫生组织未分类的骨髓增生异常/骨髓增殖性疾病及伴有环形铁粒幼细胞和显著血小板增多症的难治性贫血亚类中的预后相互作用。
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Mutations of JAK2 and TET2, but not CBL are detectable in a high portion of patients with refractory anemia with ring sideroblasts and thrombocytosis.在大部分伴有环形铁粒幼细胞和血小板增多的难治性贫血患者中可检测到JAK2和TET2的突变，但未检测到CBL的突变。
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Refractory anemia with ring sideroblasts associated with marked thrombocytosis: a mixed group exhibiting a spectrum of morphologic findings.难治性环形铁幼粒细胞性贫血伴显著血小板增多症：一个混合组，表现出一系列形态学发现。
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Occurrence of the JAK2 V617F mutation in the WHO provisional entity: myelodysplastic/myeloproliferative disease, unclassifiable-refractory anemia with ringed sideroblasts associated with marked thrombocytosis.世界卫生组织临时分类实体中JAK2 V617F突变的发生情况：骨髓增生异常/骨髓增殖性疾病，无法分类的——伴有明显血小板增多症的环形铁粒幼细胞难治性贫血。
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10
Efficacy of single-agent lenalidomide in patients with JAK2 (V617F) mutated refractory anemia with ring sideroblasts and thrombocytosis.来那度胺单药治疗 JAK2(V617F)突变型难治性环形铁幼粒细胞伴血小板增多性贫血的疗效。
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