Sun Fusheng, Ju Chuanxia, Chen Jiahong, Liu Sai, Liu Na, Wang Keke, Liu Chenguang
Qingdao Municipal Hospital, Qingdao, China.
Artif Cells Blood Substit Immobil Biotechnol. 2012 Feb;40(1-2):113-9. doi: 10.3109/10731199.2011.597759. Epub 2011 Aug 2.
We report the application of Vitamin D3 (VD(3)) in nanoparticles of oleoyl alginate ester (OAE)(OAE-VD(3)). The internalization of fluorescent OAE-VD(3) by Caco-2 cells was visualized by confocal laser scanning microscopy. In vivo pharmacokinetic studies showed that incorporation into OAE nanoparticles resulted in increased absorption of VD(3). Its application in the treatment of rickets was assayed using a model of nutritionally induced vitamin D-deficiency rickets. The results showed that the encapsulated VD(3) had better efficacy than that of the free drug in vivo. Our studies provide evidence that OAE nanoparticles are valuable as nutraceutical delivery vehicles to enhance the absorption of VD(3).
我们报道了维生素D3（VD(3)）在油酰海藻酸酯（OAE）纳米颗粒（OAE-VD(3)）中的应用。通过共聚焦激光扫描显微镜观察了Caco-2细胞对荧光OAE-VD(3)的摄取情况。体内药代动力学研究表明，将VD(3)包封于OAE纳米颗粒中可提高其吸收。利用营养性维生素D缺乏性佝偻病模型检测了其在佝偻病治疗中的应用。结果表明，包封的VD(3)在体内的疗效优于游离药物。我们的研究提供了证据，证明OAE纳米颗粒作为营养补充剂递送载体对于提高VD(3)的吸收具有重要价值。
