在发育中的心脏中心房利钠因子：心脏形态发生的路标。

Atrial natriuretic factor in the developing heart: a signpost for cardiac morphogenesis.

机构信息

Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA.

出版信息

Can J Physiol Pharmacol. 2011 Aug;89(8):533-7. doi: 10.1139/y11-051. Epub 2011 Aug 2.

Abstract

The developing heart forms during the early stages of embryogenesis, and misregulated heart development results in congenital heart defects (CHDs). To understand the molecular basis of CHDs, a deep understanding of the morphological and genetic basis of heart development is necessary. Atrial Natriuretic Factor (ANF) is an important and extremely sensitive marker for specific regions of the developing heart, as well as for disturbances in the patterning of the heart. This review summarizes the dynamic expression of ANF in the developing heart and its usefulness in understanding the early molecular defects underlying CHDs.

摘要

发育中的心脏在胚胎发生的早期形成，而心脏发育的失调会导致先天性心脏缺陷（CHD）。为了了解 CHD 的分子基础，深入了解心脏发育的形态和遗传基础是必要的。心钠素（ANF）是发育中心脏特定区域以及心脏模式形成障碍的重要且极其敏感的标志物。本综述总结了 ANF 在发育心脏中的动态表达及其在了解 CHD 潜在早期分子缺陷中的有用性。