Carayon A
Service de Biochemie médicale, CHU Pitié-Salpêtrière, Paris.
Ann Cardiol Angeiol (Paris). 1988 Dec;37(10):587-93.
Atrial natriuretic factor (ANF) is a cardiac peptide hormone whose detection led to the discovery of a new natriuretic vasomotor relaxant hormonal system where the heart plays the role of an endocrine gland. Atrial distension represents the main stimulus for the release of ANF. Its cardiovascular effects consist primarily of hypotension related to its relaxant properties, a decrease in cardiac output and a negative inotropic effect. The close relations between ANF and the heart implicate this hormone as a major factor in all cardiovascular disorders, and in particular in congestive heart failure where its plasma concentration represents an index of hemodynamic and functional disease severity. Hemodynamic changes related to valvular heart disease, whether of the mitral or aortic valve, as well as dysrhythmias have a significant effect on release of ANF. Thus, it is now well recognized that ANF, released by the heart, is implicated in the pathophysiology of cardiovascular disorders.
心房利钠因子（ANF）是一种心脏肽类激素，对它的检测促成了一个新的利钠血管舒张激素系统的发现，在这个系统中，心脏发挥着内分泌腺的作用。心房扩张是ANF释放的主要刺激因素。它对心血管系统的作用主要包括因其舒张特性导致的低血压、心输出量减少和负性肌力作用。ANF与心脏的密切关系表明，这种激素是所有心血管疾病的主要因素，尤其是在充血性心力衰竭中，其血浆浓度代表了血流动力学和功能疾病严重程度的指标。与瓣膜性心脏病（无论是二尖瓣还是主动脉瓣）相关的血流动力学变化以及心律失常对ANF的释放有显著影响。因此，现在人们已经充分认识到，心脏释放的ANF与心血管疾病的病理生理学有关。
