Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
Behav Brain Funct. 2011 Aug 1;7:29. doi: 10.1186/1744-9081-7-29.
The expanding set of genomics tools available for inbred mouse strains has renewed interest in phenotyping larger sets of strains. The present study aims to explore phenotypic variability among six commonly-used inbred mouse strains to both the rewarding and locomotor stimulating effects of cocaine in a place conditioning task, including several strains or substrains that have not yet been characterized for some or all of these behaviors.
C57BL/6J (B6), BALB/cJ (BALB), C3H/HeJ (C3H), DBA/2J (D2), FVB/NJ (FVB) and 129S1/SvImJ (129) mice were tested for conditioned place preference to 20 mg/kg cocaine.
Place preference was observed in most strains with the exception of D2 and 129. All strains showed a marked increase in locomotor activity in response to cocaine. In BALB mice, however, locomotor activation was context-dependent. Locomotor sensitization to repeated exposure to cocaine was most significant in 129 and D2 mice but was absent in FVB mice.
Genetic correlations suggest that no significant correlation between conditioned place preference, acute locomotor activation, and locomotor sensitization exists among these strains indicating that separate mechanisms underlie the psychomotor and rewarding effects of cocaine.
可用于近交系小鼠的基因组学工具不断增加，这重新激发了人们对表型分析更多近交系的兴趣。本研究旨在探讨六种常用近交系小鼠对可卡因的奖赏和运动刺激效应的表型变异性，包括一些尚未对某些或所有这些行为进行特征描述的品系或亚系。
C57BL/6J（B6）、BALB/cJ（BALB）、C3H/HeJ（C3H）、DBA/2J（D2）、FVB/NJ（FVB）和 129S1/SvImJ（129）小鼠接受 20mg/kg 可卡因的条件性位置偏爱测试。
除 D2 和 129 外，大多数品系均观察到位置偏好。所有品系对可卡因均表现出明显的运动活性增加。然而，在 BALB 小鼠中，运动激活与环境有关。129 和 D2 小鼠对可卡因的重复暴露出现显著的运动敏化，但 FVB 小鼠则没有。
遗传相关性表明，这些品系之间的条件性位置偏好、急性运动激活和运动敏化之间没有显著相关性，表明可卡因的精神运动和奖赏效应的基础是不同的机制。
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