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地高辛——是时候不再“遮遮掩掩”了?

Digoxin - time to take the gloves off?

机构信息

FY1 Doctor Jersey General Hospital, Jersey, Channel Islands.

出版信息

Int J Cardiol. 2013 Apr 15;164(3):365-7. doi: 10.1016/j.ijcard.2011.07.034. Epub 2011 Jul 31.

DOI:10.1016/j.ijcard.2011.07.034
PMID:21807421
Abstract

Digoxin has been used for hundreds of years to aid rate control in atrial fibrillation and as a positive inotrope in heart failure. Our familiarity with digoxin has allowed it to become easily prescribed even though there are data suggesting that use of digoxin may in fact result in increased mortality and pro-arrhythmia. Within this review we explain some of the outcome data associated with digoxin use to determine if it is time to take the gloves off and examine if we should still be using this drug in the 21st century.

摘要

地高辛已被使用数百年,以帮助控制心房颤动的心率,并作为心力衰竭的正性肌力药。尽管有数据表明地高辛的使用实际上可能导致死亡率增加和致心律失常,但我们对地高辛的熟悉使其变得易于开处方。在本综述中,我们解释了一些与地高辛使用相关的结果数据,以确定是否是时候采取行动,检查我们是否仍应在 21 世纪使用这种药物。

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1
Digoxin - time to take the gloves off?地高辛——是时候不再“遮遮掩掩”了?
Int J Cardiol. 2013 Apr 15;164(3):365-7. doi: 10.1016/j.ijcard.2011.07.034. Epub 2011 Jul 31.
2
Impact of Digoxin on Mortality in Patients With Atrial Fibrillation Stratified by Heart Failure: Findings From Gulf Survey of Atrial Fibrillation Events in the Middle East.地高辛对心力衰竭分层的心房颤动患者死亡率的影响:中东地区心房颤动事件海湾调查结果
J Cardiovasc Pharmacol Ther. 2016 May;21(3):273-9. doi: 10.1177/1074248415603505. Epub 2015 Sep 3.
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Use of digoxin for heart failure and atrial fibrillation in elderly patients.地高辛在老年患者心力衰竭和心房颤动中的应用。
Am J Geriatr Pharmacother. 2010 Oct;8(5):419-27. doi: 10.1016/j.amjopharm.2010.10.001.
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[Posologic factors of digoxin in Catalonia].[加泰罗尼亚地区地高辛的剂量因素]
An Med Interna. 1999 Oct;16(10):543-4.
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Relation of digoxin use in atrial fibrillation and the risk of all-cause mortality in patients ≥65 years of age with versus without heart failure.在≥65 岁伴或不伴心力衰竭的心房颤动患者中,地高辛的使用与全因死亡率的关系。
Am J Cardiol. 2014 Aug 1;114(3):401-6. doi: 10.1016/j.amjcard.2014.05.013. Epub 2014 May 16.
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Digoxin Is Associated With Increased All-cause Mortality in Patients With Atrial Fibrillation Regardless of Concomitant Heart Failure: A Meta-analysis.无论是否合并心力衰竭,地高辛与房颤患者全因死亡率增加相关:一项荟萃分析。
J Cardiovasc Pharmacol. 2015 Sep;66(3):270-5. doi: 10.1097/FJC.0000000000000274.
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Digoxin mortality in heart failure and atrial fibrillation.
Eur Heart J. 2015 Aug 7;36(30):1944-5.
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Is there a role for digoxin in atrial fibrillation without heart failure?地高辛在无心力衰竭的心房颤动中是否有作用?
Cardiol J. 2009;16(5):483-6.
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Digoxin in patients with atrial fibrillation and heart failure: A meta-analysis.心房颤动合并心力衰竭患者使用地高辛的荟萃分析。
Int J Cardiol. 2015 Jun 1;188:99-101. doi: 10.1016/j.ijcard.2015.04.031. Epub 2015 Apr 6.
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Dilated cardiomyopathy and potentially deadly digoxin.扩张型心肌病与可能致命的地高辛。
S Afr Med J. 2011 May 25;101(6):388, 390.

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