Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA.
J Leukoc Biol. 2011 Nov;90(5):883-95. doi: 10.1189/jlb.0311134. Epub 2011 Aug 1.
This review updates the basic biology of lung DCs and their functions. Lung DCs have taken center stage as cellular therapeutic targets in new vaccine strategies for the treatment of diverse human disorders, including asthma, allergic lung inflammation, lung cancer, and infectious lung disease. The anatomical distribution of lung DCs, as well as the division of labor between their subsets, aids their ability to recognize and endocytose foreign substances and to process antigens. DCs can induce tolerance in or activate naïve T cells, making lung DCs well-suited to their role as lung sentinels. Lung DCs serve as a functional signaling/sensing unit to maintain lung homeostasis and orchestrate host responses to benign and harmful foreign substances.
这篇综述更新了肺树突状细胞的基础生物学及其功能。肺树突状细胞已成为新型疫苗策略中细胞治疗靶点，用于治疗多种人类疾病，包括哮喘、过敏性肺部炎症、肺癌和肺部传染病。肺树突状细胞的解剖分布以及它们亚群之间的分工，有助于它们识别和内吞外来物质和处理抗原。树突状细胞可以诱导或激活幼稚 T 细胞耐受，使肺树突状细胞非常适合作为肺部哨兵的角色。肺树突状细胞作为一个功能性信号/传感单位，维持肺内环境稳态，并协调宿主对良性和有害外来物质的反应。
