Division of Gastroenterology and Hepatology, Department of Medicine, Strong Memorial Hospital, University of Rochester Mediacal Center, University of Rochester, Rochester, NY 14642, USA.
Gastroenterol Res Pract. 2011;2011:971938. doi: 10.1155/2011/971938. Epub 2011 Jul 26.
There is increased investigation of the human microbiome as it relates to health and disease. Dysbiosis is implicated in various clinical conditions including inflammatory bowel disease (IBD). Probiotics have been explored as a potential treatment for IBD and other diseases. The mechanism of action for probiotics has yet to be fully elucidated. This paper discusses novel mechanisms of action for probiotics involving anti-inflammatory signaling pathways. We highlight recent progress in probiotics and nuclear receptor signaling, such as peroxisome-proliferator-activated receptor gamma (PPARγ) and vitamin D receptor (VDR). We also discuss future areas of investigation.
人们越来越关注人类微生物组与健康和疾病的关系。肠道菌群失调与各种临床情况有关，包括炎症性肠病（IBD）。益生菌已被探索作为治疗 IBD 和其他疾病的一种潜在方法。益生菌的作用机制尚未完全阐明。本文讨论了益生菌的新型作用机制，包括抗炎信号通路。我们重点介绍了益生菌与核受体信号转导（如过氧化物酶体增殖物激活受体 γ（PPARγ）和维生素 D 受体（VDR））的最新进展。我们还讨论了未来的研究领域。
