Barral Sumara Marques, Araujo Ivana Duval, Vidigal Paula Vieira Teixeira, Mayrink Cláudio Alvarenga Campos, Araujo Adriana Duval, Costa Paulo Roberto da
Department of Surgery, UFMG, Belo Horizonte, MG, Brazil.
Acta Cir Bras. 2011 Aug;26(4):314-9. doi: 10.1590/s0102-86502011000400012.
To assess the viability of McFarlane skin flaps in rats with administration of sildenafil.
Twenty Wistar rats were distributed into two groups: Control (dorsal skin flap, subdermal application of saline solution at 0.9%) and Study (dorsal skin flap, subdermal application of sildenafil). Seven days after the surgery, flaps were photographed and graphically rendered. Then, they were analyzed with AutoCAD software. Three biopsies (proximal, medial and distal) of each flap were collected for histological analysis.
Macroscopic analysis showed that animals of the study group had greater necrotic areas (p=0.003) in the dorsal skin flaps. Additionally, histological analysis of the distal third of these flaps showed a tendency to less granulated tissue formation in animals treated with sildenafil.
Sildenafil subdermally was associated with lower viability of the random skin flap in rats.
评估给予西地那非后大鼠麦克法兰皮瓣的存活能力。
将20只Wistar大鼠分为两组：对照组（背部皮瓣，皮下注射0.9%的生理盐水）和研究组（背部皮瓣，皮下注射西地那非）。术后7天，对皮瓣进行拍照并绘制图形。然后，使用AutoCAD软件进行分析。收集每个皮瓣的三块活检组织（近端、中间和远端）进行组织学分析。
宏观分析表明，研究组动物的背部皮瓣坏死面积更大（p = 0.003）。此外，对这些皮瓣远端三分之一的组织学分析显示，接受西地那非治疗的动物中肉芽组织形成的趋势较小。
皮下注射西地那非与大鼠随意皮瓣的较低存活能力相关。
