Department of Infectious Diseases, Singapore General Hospital, Outram Road, Singapore 169608.
Singapore Med J. 2011 Jul;52(7):481-5.
The 2009 (H1N1) influenza A pandemic started in April 2009 and has since spread globally. We have noticed that critically ill patients with confirmed pandemic 2009 (H1N1) influenza A require mechanical ventilation. This paper describes the use of intravenous zanamivir in this group of patients.
Patients who had severe pneumonia with 2009 (H1N1) influenza A and required intravenous zanamivir were referred to the Infectious Diseases Department of our institution. Clinical data was collected from these patients. Clinical samples were sent to the National Public Health Laboratory for sequencing.
A total of five patients used intravenous zanamivir from April 8 to May 8, 2010. Only one death was reported. There were no side effects attributable to the use of intravenous zanamivir. H275 mutation, which confers resistance to oseltamivir, was seen in a subpopulation of the virus in one case.
Physicians can consider using intravenous zanamivir for the treatment of critically ill patients with 2009 (H1N1) influenza A infection.
2009 年（H1N1）甲型流感大流行始于 2009 年 4 月，并已在全球范围内传播。我们注意到，确诊为 2009 年（H1N1）甲型流感的危重症患者需要机械通气。本文介绍了在这组患者中使用静脉扎那米韦的情况。
我院传染病科收治了患有严重肺炎且甲型流感 2009（H1N1）阳性需要静脉扎那米韦的患者。从这些患者中收集临床数据。临床标本被送往国家公共卫生实验室进行测序。
2010 年 4 月 8 日至 5 月 8 日期间，共有 5 名患者使用了静脉扎那米韦。仅报告了 1 例死亡。未发现与静脉扎那米韦使用相关的副作用。在一个病例中，病毒的一个亚群出现了对奥司他韦耐药的 H275 突变。
医生可以考虑使用静脉扎那米韦治疗 2009 年（H1N1）甲型流感感染的危重症患者。
Zotero 插件