Choe Uh-Joo, Sun Victor Z, Tan James-Kevin Y, Kamei Daniel T
Department of Bioengineering, University of California, Los Angeles, CA, 90095, USA.
Top Curr Chem. 2012;310:117-34. doi: 10.1007/128_2011_209.
The development of nanoscale drug delivery vehicles is an exciting field due to the ability of these vehicles to improve the pharmacokinetic and pharmacodynamic properties of existing therapeutics. These vehicles can improve drug effectiveness and safety by providing benefits such as increased blood circulation, targeted delivery, and controlled release. With regard to the building blocks, amphiphilic polypeptide and polypeptide hybrid (i.e., a macromolecule comprised of a polypeptide and another type of polymer) systems have been recently investigated for their abilities to self-assemble into vesicles. Advances in synthesis methodologies have allowed the development and characterization of many different amphiphilic polypeptide and polypeptide hybrid systems. In this review, we will discuss these vesicle-forming materials in terms of their synthesis, processing, and characterization. In addition, current efforts to use them for drug delivery purposes will be discussed.
纳米级药物递送载体的研发是一个令人兴奋的领域，因为这些载体能够改善现有治疗药物的药代动力学和药效学特性。这些载体可通过提供诸如延长血液循环时间、靶向递送和控释等益处来提高药物疗效和安全性。关于构建材料，两亲性多肽和多肽杂化体（即由多肽和另一种聚合物组成的大分子）系统最近因其自组装成囊泡的能力而受到研究。合成方法学的进展使得许多不同的两亲性多肽和多肽杂化体系统得以开发和表征。在本综述中，我们将从合成、加工和表征方面讨论这些形成囊泡的材料。此外，还将讨论目前将它们用于药物递送目的的研究工作。
