Bondarenko V M
Zh Mikrobiol Epidemiol Immunobiol. 2011 May-Jun(3):94-9.
The analysis of opportunistic bacteria phenotypic and genetic virulence markers indicates that pathogenicity formation is based on a structural modification of bacterial DNA which is linked with migration of interbacterial pathogenicity "islands" genetic determinants. Structural organization features of these mobile genetic elements determine high expression probability, and PCR detection of pathogenicity "islands" determinants that control adhesins, invasins, cytotoxic and cytolitic toxines synthesis may indicate etiopathogenetic significance of clinical isolates.
对机会性细菌表型和基因毒力标志物的分析表明,致病性的形成基于细菌DNA的结构修饰,这与细菌间致病性“岛”遗传决定因素的迁移有关。这些移动遗传元件的结构组织特征决定了高表达概率,而对控制黏附素、侵袭素、细胞毒性和细胞溶解性毒素合成的致病性“岛”决定因素进行PCR检测,可能表明临床分离株的病因病理意义。